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Message: <blockquote data-quote="madman" data-source="post: 123553" data-attributes="member: 13851">As you should be aware seeing as your SHBG was so high pre-trt you will need to run a higher TT in order to achieve a healthy FT.You are missing a critical test which is your FT and although your TT is extremely high we have no idea where your FT sits as even though it is good to know where your TT levels are.....FT is what truly matters as it is the unbound active fraction of testosterone responsible for the positive benefits.Most uninformed doctors treating men with trt only test TT.....rarely ever FT or SHBG which are critical and many physicians do not even check e2 and if they do it is using the wrong e2 test which is the standard meant for women.The estradiol sensitive test (LC/MS-MS) is now available in Ontario and a few other provinces but only through Dynacare as Lifelabs is still testing with the standard assay.</blockquote>