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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Very high FT on 70mg/wk?
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<blockquote data-quote="Cataceous" data-source="post: 220028" data-attributes="member: 38109"><p>Estriol is said to have about 1/100th the potency of estradiol, which knocks it down to a relatively trivial 20 mcg estradiol-equivalent per dose. If it is really only increasing the effective dose by 4% then I'm thinking it's not likely to be a problem.</p><p></p><p>I'd expect the pharmacokinetics to be similar to what's seen with topical testosterone; there is no ester. Ideally the skin is acting as a reservoir, slowing absorption and making once-daily dosing possible. But two smaller doses would certainly produce more even levels. With topical estradiol I didn't seem to run into the absorption problems I encountered with topical testosterone—perhaps due to the much lower quantities involved.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 220028, member: 38109"] Estriol is said to have about 1/100th the potency of estradiol, which knocks it down to a relatively trivial 20 mcg estradiol-equivalent per dose. If it is really only increasing the effective dose by 4% then I'm thinking it's not likely to be a problem. I'd expect the pharmacokinetics to be similar to what's seen with topical testosterone; there is no ester. Ideally the skin is acting as a reservoir, slowing absorption and making once-daily dosing possible. But two smaller doses would certainly produce more even levels. With topical estradiol I didn't seem to run into the absorption problems I encountered with topical testosterone—perhaps due to the much lower quantities involved. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Very high FT on 70mg/wk?
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