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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Variance in Peak and Trough T Levels in Men Using Intramuscular T Injections
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<blockquote data-quote="madman" data-source="post: 119534" data-attributes="member: 13851"><p><strong>MP85-14 VARIANCE IN PEAK AND TROUGH TESTOSTERONE LEVELS IN MEN USING INTRAMUSCULAR TESTOSTERONE</strong></p><p><span style="color: rgb(184, 49, 47)"><em>Bruno Nascimento*, Helen L Bernie, Elizabeth Schofield, John P. Mulhall, New York, NY</em></span></p><p></p><p></p><p><strong><span style="color: rgb(0, 0, 0)">INTRODUCTION AND OBJECTIVES</span></strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong><em>In men using intramuscular testosterone (IM T), clinical experience shows us that, despite stable dosing and frequency,</em></strong></span><em><span style="color: rgb(44, 130, 201)"><strong> total testosterone peak (Tp) and trough (Tt) levels are highly variable,</strong></span> thus challenging the clinician to make a decision regarding dose adjustments. The goal of this study was to define the variability in T levels in a population of men on IM T.</em></p><p></p><p><strong><span style="color: rgb(0, 0, 0)">METHODS</span></strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong><em>Patients with 3 consecutive Tp and Tt levels available, while on a stable dose and interval of IM T cypionate were analyzed.</em></strong></span><em> <span style="color: rgb(44, 130, 201)"><strong>All patients were instructed as follows: Tp levels to be checked 18 hours after IM T injection, and Tt levels to be drawn the following week on the day of injection, prior to injecting the next dose.</strong></span> </em><span style="color: rgb(251, 160, 38)"><strong><em>We report on Tp, Tt, and D (Tp-Tt). T level was measured using LC/MS-MS. To assess for T level variation across the 3 cycles, we calculated mean change in Tp and Tt as well as maximal change in Tp and Tt. Distribution analysis was performed to assess for variance distribution.</em></strong></span></p><p></p><p><strong><span style="color: rgb(0, 0, 0)">RESULTS</span></strong></p><p></p><p><em><strong>29 patients met the inclusion criteria equating to 174 total T levels analyzed. The mean</strong><span style="color: rgb(0, 0, 0)"><strong> age was 52 ± 28y.</strong> </span><strong>Dose distribution was: <span style="color: rgb(0, 0, 0)">3% receiving 40mg, 10% 60mg, 35% 80mg, 38% 100mg, 7% 120mg, and 7% receiving other doses. 83% were injecting every 7 days. </span></strong><span style="color: rgb(44, 130, 201)"><strong>Averaged over 3 cycles, mean Tp was 910 ± 165 ng/dl;</strong></span> <span style="color: rgb(184, 49, 47)"><strong>mean Tt was 558 ± 80 ng/dl</strong></span><strong><span style="color: rgb(184, 49, 47)">,</span> and </strong><span style="color: rgb(26, 188, 156)"><strong>mean D was 352 ± 154.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>Mean Tp variance was 210 ± 99 ng/dl representing a 23% change from cycle to cycle. </strong></span><span style="color: rgb(184, 49, 47)"><strong>Mean Tt variance = 102 ± 63 ng/dl (17.5% change). </strong></span><span style="color: rgb(44, 130, 201)"><strong>Averaged over all patients, maximum Tp change was 315 ± 148 ng/dl, </strong></span><span style="color: rgb(184, 49, 47)"><strong>and maximum Tt change was 152 ± 94 ng/dl, representing a maximum change of 37% and 26% respectively.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>In distribution analysis, 25% of patients had a maximum Tp change greater than 51%</strong></span> </em><span style="color: rgb(184, 49, 47)"><strong><em>and a maximum Tt change of 35%.</em></strong></span></p><p></p><p>[ATTACH=full]13689[/ATTACH]</p><p></p><p></p><p><strong><span style="color: rgb(0, 0, 0)">CONCLUSIONS</span></strong></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong><em>In our population of patients on stable IM T dose, there was a</em></strong></span><strong><em> <span style="color: rgb(44, 130, 201)">wide mean variation in both Tp (23%) </span><span style="color: rgb(184, 49, 47)">and Tt (17.5%).</span><span style="color: rgb(44, 130, 201)"> In addition to that, 25% of patients had a maximum Tp change greater than 50% </span><span style="color: rgb(184, 49, 47)">and a maximum Tt change greater than 35%. </span></em></strong><em><strong>Clinicians should be aware of this high variability in levels when deciding on dose adjustment.</strong></em></p><p></p><p>Source of Funding: None</p></blockquote><p></p>
[QUOTE="madman, post: 119534, member: 13851"] [B]MP85-14 VARIANCE IN PEAK AND TROUGH TESTOSTERONE LEVELS IN MEN USING INTRAMUSCULAR TESTOSTERONE[/B] [COLOR=rgb(184, 49, 47)][I]Bruno Nascimento*, Helen L Bernie, Elizabeth Schofield, John P. Mulhall, New York, NY[/I][/COLOR] [B][COLOR=rgb(0, 0, 0)]INTRODUCTION AND OBJECTIVES[/COLOR][/B] [COLOR=rgb(184, 49, 47)][B][I]In men using intramuscular testosterone (IM T), clinical experience shows us that, despite stable dosing and frequency,[/I][/B][/COLOR][I][COLOR=rgb(44, 130, 201)][B] total testosterone peak (Tp) and trough (Tt) levels are highly variable,[/B][/COLOR] thus challenging the clinician to make a decision regarding dose adjustments. The goal of this study was to define the variability in T levels in a population of men on IM T.[/I] [B][COLOR=rgb(0, 0, 0)]METHODS[/COLOR][/B] [COLOR=rgb(184, 49, 47)][B][I]Patients with 3 consecutive Tp and Tt levels available, while on a stable dose and interval of IM T cypionate were analyzed.[/I][/B][/COLOR][I] [COLOR=rgb(44, 130, 201)][B]All patients were instructed as follows: Tp levels to be checked 18 hours after IM T injection, and Tt levels to be drawn the following week on the day of injection, prior to injecting the next dose.[/B][/COLOR] [/I][COLOR=rgb(251, 160, 38)][B][I]We report on Tp, Tt, and D (Tp-Tt). T level was measured using LC/MS-MS. To assess for T level variation across the 3 cycles, we calculated mean change in Tp and Tt as well as maximal change in Tp and Tt. Distribution analysis was performed to assess for variance distribution.[/I][/B][/COLOR] [B][COLOR=rgb(0, 0, 0)]RESULTS[/COLOR][/B] [I][B]29 patients met the inclusion criteria equating to 174 total T levels analyzed. The mean[/B][COLOR=rgb(0, 0, 0)][B] age was 52 ± 28y.[/B] [/COLOR][B]Dose distribution was: [COLOR=rgb(0, 0, 0)]3% receiving 40mg, 10% 60mg, 35% 80mg, 38% 100mg, 7% 120mg, and 7% receiving other doses. 83% were injecting every 7 days. [/COLOR][/B][COLOR=rgb(44, 130, 201)][B]Averaged over 3 cycles, mean Tp was 910 ± 165 ng/dl;[/B][/COLOR] [COLOR=rgb(184, 49, 47)][B]mean Tt was 558 ± 80 ng/dl[/B][/COLOR][B][COLOR=rgb(184, 49, 47)],[/COLOR] and [/B][COLOR=rgb(26, 188, 156)][B]mean D was 352 ± 154.[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]Mean Tp variance was 210 ± 99 ng/dl representing a 23% change from cycle to cycle. [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]Mean Tt variance = 102 ± 63 ng/dl (17.5% change). [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]Averaged over all patients, maximum Tp change was 315 ± 148 ng/dl, [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]and maximum Tt change was 152 ± 94 ng/dl, representing a maximum change of 37% and 26% respectively.[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]In distribution analysis, 25% of patients had a maximum Tp change greater than 51%[/B][/COLOR] [/I][COLOR=rgb(184, 49, 47)][B][I]and a maximum Tt change of 35%.[/I][/B][/COLOR] [ATTACH type="full" alt="testosterone injections variability.jpg"]13689[/ATTACH] [B][COLOR=rgb(0, 0, 0)]CONCLUSIONS[/COLOR][/B] [COLOR=rgb(0, 0, 0)][B][I]In our population of patients on stable IM T dose, there was a[/I][/B][/COLOR][B][I] [COLOR=rgb(44, 130, 201)]wide mean variation in both Tp (23%) [/COLOR][COLOR=rgb(184, 49, 47)]and Tt (17.5%).[/COLOR][COLOR=rgb(44, 130, 201)] In addition to that, 25% of patients had a maximum Tp change greater than 50% [/COLOR][COLOR=rgb(184, 49, 47)]and a maximum Tt change greater than 35%. [/COLOR][/I][/B][I][B]Clinicians should be aware of this high variability in levels when deciding on dose adjustment.[/B][/I] Source of Funding: None [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Variance in Peak and Trough T Levels in Men Using Intramuscular T Injections
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