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Variability in the Assessment of Reproductive Hormone Levels During a Day
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<blockquote data-quote="Nelson Vergel" data-source="post: 269923" data-attributes="member: 3"><p><h3>Understanding Variability in Measuring Reproductive Hormones</h3><h4>Overview</h4><p><strong>Objective:</strong> The aim was to determine how accurately a single hormone test reflects the daily hormonal changes in the body. This was done by examining data from detailed hormone tests conducted over several hours on individuals who received a saline placebo.</p><p></p><h4>Study Design</h4><p>This was a retrospective study, meaning it looked back at data from previous studies that focused on reproductive hormones.</p><p></p><h4>Participants</h4><p>The study included 266 participants:</p><p></p><ul> <li data-xf-list-type="ul">142 healthy men and women</li> <li data-xf-list-type="ul">124 individuals with reproductive health issues, including:<ul> <li data-xf-list-type="ul">11 with functional hypothalamic amenorrhea (FHA), a condition where menstrual periods stop due to stress or weight loss</li> <li data-xf-list-type="ul">6 with polycystic ovary syndrome (PCOS)</li> <li data-xf-list-type="ul">62 women and 32 men with hypoactive sexual desire disorder (HSDD)</li> <li data-xf-list-type="ul">13 post-menopausal women</li> </ul></li> </ul><h4>Method</h4><p>The researchers used data from these individuals who had undergone detailed hormone tests. They analyzed the variations in hormone levels due to natural fluctuations throughout the day, changes caused by eating, and other factors. They used statistical methods like the coefficient of variation (CV) and entropy to measure these variations.</p><p></p><h4>Key Findings</h4> <ul> <li data-xf-list-type="ul">Morning levels of reproductive hormones were generally higher than the average levels during the day.</li> <li data-xf-list-type="ul">The hormone luteinizing hormone (LH) showed the most variation, followed by sex hormones like testosterone and estradiol. Follicle-stimulating hormone (FSH) had the least variation.</li> <li data-xf-list-type="ul">In healthy men, testosterone levels decreased from morning to evening by about 15%.</li> <li data-xf-list-type="ul">Testosterone levels changed more significantly after a regular meal compared to fasting or consuming glucose.</li> </ul><h4>Conclusion</h4><p>This study helps understand how reliable a single hormone test is in assessing reproductive hormone levels, considering the natural variability in these hormones.</p><p></p><h4>Key Terms</h4> <ul> <li data-xf-list-type="ul">Diurnal: Related to daily cycles</li> <li data-xf-list-type="ul">Feeding: The impact of eating on hormone levels</li> <li data-xf-list-type="ul">Hypogonadism: A condition where the body doesn't produce enough sex hormones</li> <li data-xf-list-type="ul">Reproductive hormones: Hormones that play a role in sexual function and reproduction</li> <li data-xf-list-type="ul">Variability: The degree to which these hormone levels fluctuate</li> </ul></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 269923, member: 3"] [HEADING=2]Understanding Variability in Measuring Reproductive Hormones[/HEADING] [HEADING=3]Overview[/HEADING] [B]Objective:[/B] The aim was to determine how accurately a single hormone test reflects the daily hormonal changes in the body. This was done by examining data from detailed hormone tests conducted over several hours on individuals who received a saline placebo. [HEADING=3]Study Design[/HEADING] This was a retrospective study, meaning it looked back at data from previous studies that focused on reproductive hormones. [HEADING=3]Participants[/HEADING] The study included 266 participants: [LIST] [*]142 healthy men and women [*]124 individuals with reproductive health issues, including: [LIST] [*]11 with functional hypothalamic amenorrhea (FHA), a condition where menstrual periods stop due to stress or weight loss [*]6 with polycystic ovary syndrome (PCOS) [*]62 women and 32 men with hypoactive sexual desire disorder (HSDD) [*]13 post-menopausal women [/LIST] [/LIST] [HEADING=3]Method[/HEADING] The researchers used data from these individuals who had undergone detailed hormone tests. They analyzed the variations in hormone levels due to natural fluctuations throughout the day, changes caused by eating, and other factors. They used statistical methods like the coefficient of variation (CV) and entropy to measure these variations. [HEADING=3]Key Findings[/HEADING] [LIST] [*]Morning levels of reproductive hormones were generally higher than the average levels during the day. [*]The hormone luteinizing hormone (LH) showed the most variation, followed by sex hormones like testosterone and estradiol. Follicle-stimulating hormone (FSH) had the least variation. [*]In healthy men, testosterone levels decreased from morning to evening by about 15%. [*]Testosterone levels changed more significantly after a regular meal compared to fasting or consuming glucose. [/LIST] [HEADING=3]Conclusion[/HEADING] This study helps understand how reliable a single hormone test is in assessing reproductive hormone levels, considering the natural variability in these hormones. [HEADING=3]Key Terms[/HEADING] [LIST] [*]Diurnal: Related to daily cycles [*]Feeding: The impact of eating on hormone levels [*]Hypogonadism: A condition where the body doesn't produce enough sex hormones [*]Reproductive hormones: Hormones that play a role in sexual function and reproduction [*]Variability: The degree to which these hormone levels fluctuate [/LIST] [/QUOTE]
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Variability in the Assessment of Reproductive Hormone Levels During a Day
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