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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Using protocol change to spike dopamine?
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<blockquote data-quote="Gman86" data-source="post: 231234" data-attributes="member: 15043"><p>Here’s a couple anecdotes. One where a guy is using it in conjunction with TRT, and the other is of a guy using some form of selegiline for around 22 years. Anytime someone reports feeling angry and irritable, it usually seems to be a case of simply taking too much. Selegiline has a very high absorption rate when taken sublingually compared to taken orally. I think a lot of people underestimate how much selegiline they’re getting in their system when taking sublingually. Taking it sublingually can increase the amount u absorb by up to 8x, compared to taking the same dose orally. And a lot of the original data is based on taking it orally from my understanding. So when the original data says that the people in the study took 5mg orally, people take that and think that taking 2.5mg sublingually isn’t much. But u could be getting as much in ur bloodstream taking 2.5mg sublingually as someone taking 20mg orally. And most people take it sublingually from what I’ve seen. So I think people just end up taking more than they need to. From all the positive anecdotes that I’ve seen over the years, most of these people are using sublingual doses of 1.25mg either daily, EOD, and quite a few just 1-3 times per week</p><table class='post-table ' style='width: 100%'><tr><td ><p><br /> <a href="https://www.reddit.com/user/validstatement/" target="_blank">validstatement</a><br /> 5y</p></td><td></td></tr></table>The combination of selegiline and testosterone replacement therapy has made me one of the most productive, motivated, and organized people I know. Complete reversal in personality, I really like it. I can also be extremely intense to be around, though. I'm sorry you've found it hasn't worked very well for you. I also get very irritable with selegiline if I take too much. Try 1mg every other day. That's my sweet spot. Additionally, I find high dosages of fish oil alleviates the aggression and irritability. About 4-8g, daily. Consider trying that. Good luck!</p><p></p><table class='post-table ' style='width: 100%'><tr><td ><p><br /> <a href="https://www.reddit.com/user/doogiehowitzer1/" target="_blank">doogiehowitzer1</a><br /> 208d</p></td><td></td></tr></table>I’ve been taking selegiline in some form or another for 22 years now. Always in low doses varying between 1-5mgs. I am 41 years old now, and many people regularity comment on my youthful appearance.</p><p>-It is energizing and uplifting for me. Although I already have a naturally high tolerance to stimulants. It is very motivating and an aphrodisiac. It has certainly been a nootropic for me and aided me in my career. There have been strategy meetings where I would suddenly have bouts of creativity or insight which I feel would not have occurred if I hadn’t been taking it. But I can’t be certain if that’s placebo or not.</p><p>-If you find it to be overly stimulating or creating other negative side effects back your dosing off to every other day or every 2-3 days. I have used varying dosing schemes over the years (always in doses less than <5mg.) I have settled on my preferred dose being 1mg sublingual every day or every other day depending on how I am feeling. I have never had a single negative effect that I can discern. I drink wine, eat whatever I want, have combined I with other stimulants in the past for whatever reason at the time. All good. I am in great health as well though. I run 5 days a week and lift weights 2 days weekly. I do credit selegiline with giving me the motivation and energy to continue working out like that.</p><p>-I realize I may be an outlier. There are many reports in the internet of selegiline working well initially for many only to cause problems which led to discontinuation later on. My belief is that most of these are due to taking too much. Dr Knoll himself advised a very conservative dosing regimen which is not being followed in these negative reviews.</p></blockquote><p></p>
[QUOTE="Gman86, post: 231234, member: 15043"] Here’s a couple anecdotes. One where a guy is using it in conjunction with TRT, and the other is of a guy using some form of selegiline for around 22 years. Anytime someone reports feeling angry and irritable, it usually seems to be a case of simply taking too much. Selegiline has a very high absorption rate when taken sublingually compared to taken orally. I think a lot of people underestimate how much selegiline they’re getting in their system when taking sublingually. Taking it sublingually can increase the amount u absorb by up to 8x, compared to taking the same dose orally. And a lot of the original data is based on taking it orally from my understanding. So when the original data says that the people in the study took 5mg orally, people take that and think that taking 2.5mg sublingually isn’t much. But u could be getting as much in ur bloodstream taking 2.5mg sublingually as someone taking 20mg orally. And most people take it sublingually from what I’ve seen. So I think people just end up taking more than they need to. From all the positive anecdotes that I’ve seen over the years, most of these people are using sublingual doses of 1.25mg either daily, EOD, and quite a few just 1-3 times per week [TABLE][TR][TD] [URL='https://www.reddit.com/user/validstatement/']validstatement[/URL] 5y [/TD] [TD] [/TD][/TR][/TABLE] The combination of selegiline and testosterone replacement therapy has made me one of the most productive, motivated, and organized people I know. Complete reversal in personality, I really like it. I can also be extremely intense to be around, though. I'm sorry you've found it hasn't worked very well for you. I also get very irritable with selegiline if I take too much. Try 1mg every other day. That's my sweet spot. Additionally, I find high dosages of fish oil alleviates the aggression and irritability. About 4-8g, daily. Consider trying that. Good luck! [TABLE][TR][TD] [URL='https://www.reddit.com/user/doogiehowitzer1/']doogiehowitzer1[/URL] 208d [/TD] [TD] [/TD][/TR][/TABLE] I’ve been taking selegiline in some form or another for 22 years now. Always in low doses varying between 1-5mgs. I am 41 years old now, and many people regularity comment on my youthful appearance. -It is energizing and uplifting for me. Although I already have a naturally high tolerance to stimulants. It is very motivating and an aphrodisiac. It has certainly been a nootropic for me and aided me in my career. There have been strategy meetings where I would suddenly have bouts of creativity or insight which I feel would not have occurred if I hadn’t been taking it. But I can’t be certain if that’s placebo or not. -If you find it to be overly stimulating or creating other negative side effects back your dosing off to every other day or every 2-3 days. I have used varying dosing schemes over the years (always in doses less than <5mg.) I have settled on my preferred dose being 1mg sublingual every day or every other day depending on how I am feeling. I have never had a single negative effect that I can discern. I drink wine, eat whatever I want, have combined I with other stimulants in the past for whatever reason at the time. All good. I am in great health as well though. I run 5 days a week and lift weights 2 days weekly. I do credit selegiline with giving me the motivation and energy to continue working out like that. -I realize I may be an outlier. There are many reports in the internet of selegiline working well initially for many only to cause problems which led to discontinuation later on. My belief is that most of these are due to taking too much. Dr Knoll himself advised a very conservative dosing regimen which is not being followed in these negative reviews. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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Using protocol change to spike dopamine?
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