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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Using protocol change to spike dopamine?
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<blockquote data-quote="FunkOdyssey" data-source="post: 231227" data-attributes="member: 44064"><p>My experience with selegiline has been pretty negative in doses between 2.5 mg and 5 mg daily. I felt that the initial benefits in mood and motivation waned over time, while I became gradually more and more irritable and angry. After some months I was a raging a-hole to people around me, with no patience for obstacles or setbacks.</p><p></p><p>I also have experience with amphetamine ADHD drugs and they cause me urinary tract inflammation that was duplicated by selegiline. I attributed that to the amphetamine metabolites.</p><p></p><p>I was in my 20's when I last used it and it seems possible that it is more useful at older ages if mao-b has increased. While selegiline has a honeymoon period like so many dopaminergic substances, the low dose mao-b selective doses of selegiline do not improve depression in studies -- you need higher doses that also inhibit mao-a for that effect. If I knew of 100 people that experimented with selegiline, there were probably only 2 or 3 still taking it years later. Again though, it was a younger crowd.</p><p></p><p>If you really want to dive down this rabbit hole, search for selegiline / deprenyl on longecity.org. There must be hundreds of threads and thousands of posts on it there, stretching back to the early 2000's.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 231227, member: 44064"] My experience with selegiline has been pretty negative in doses between 2.5 mg and 5 mg daily. I felt that the initial benefits in mood and motivation waned over time, while I became gradually more and more irritable and angry. After some months I was a raging a-hole to people around me, with no patience for obstacles or setbacks. I also have experience with amphetamine ADHD drugs and they cause me urinary tract inflammation that was duplicated by selegiline. I attributed that to the amphetamine metabolites. I was in my 20's when I last used it and it seems possible that it is more useful at older ages if mao-b has increased. While selegiline has a honeymoon period like so many dopaminergic substances, the low dose mao-b selective doses of selegiline do not improve depression in studies -- you need higher doses that also inhibit mao-a for that effect. If I knew of 100 people that experimented with selegiline, there were probably only 2 or 3 still taking it years later. Again though, it was a younger crowd. If you really want to dive down this rabbit hole, search for selegiline / deprenyl on longecity.org. There must be hundreds of threads and thousands of posts on it there, stretching back to the early 2000's. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Using protocol change to spike dopamine?
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