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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
"Urinary-derived hCG preparations are highly carcinogenic"
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<blockquote data-quote="testiculus" data-source="post: 244647" data-attributes="member: 17128"><p>I've spent some time now reading some of the L. Cole papers. To summarize he has identified HCG molecules that that are present in HCG producing tumors and are also present in urine derived HCG pharmaceuticals. He has identified plausible mechanisms by which these HCG molecules promote cancer. However the studies are all in vitro. No mouse model studies that I can find. Another problem that isn't discussed is the one of concentrations. Just because a molecule can promote cancer, doesn't mean that it will. The bigger question is what concentration of a molecule is necessary to promote cancer. In an HCG producing tumor one can imagine that the local concentration of these molecules could reach a much higher level than that which occurs from exogenous HCG administration. As the author acknowledges, there are no studies looking at the incidence of cancer in long term users of exogenous HCG. The only other line of research I can think of to look into is the epidemiological data on cancer in women associated with pregnancies. Since these HCG molecules are produced during pregnancy in women, an increase in cancer rates associated with pregnancies could be an indicator that this is a real risk. Unfortunately the picture here is mixed and unclear. There is a short term increase in cancer risk in women following pregnancy. However the lifetime risk of cancer is decreased with pregnancy vs no pregnancy. And further the risk of some cancers are reduced with each successive pregnancy. The only place where cancer risk and exogenous HCG has been studied is in IVF. Typically a single dose of 5000IU is used for each round of IVF. Studies of of IVF patients generally have not identified an increase in cancer risk.</p><p></p><p>So not a lot of clarity. I think it makes sense to avoid HCG if you have active cancer. Outside of that there may be a risk associated with urinary derived HCG, so it comes down to individual risk tolerance.</p></blockquote><p></p>
[QUOTE="testiculus, post: 244647, member: 17128"] I've spent some time now reading some of the L. Cole papers. To summarize he has identified HCG molecules that that are present in HCG producing tumors and are also present in urine derived HCG pharmaceuticals. He has identified plausible mechanisms by which these HCG molecules promote cancer. However the studies are all in vitro. No mouse model studies that I can find. Another problem that isn't discussed is the one of concentrations. Just because a molecule can promote cancer, doesn't mean that it will. The bigger question is what concentration of a molecule is necessary to promote cancer. In an HCG producing tumor one can imagine that the local concentration of these molecules could reach a much higher level than that which occurs from exogenous HCG administration. As the author acknowledges, there are no studies looking at the incidence of cancer in long term users of exogenous HCG. The only other line of research I can think of to look into is the epidemiological data on cancer in women associated with pregnancies. Since these HCG molecules are produced during pregnancy in women, an increase in cancer rates associated with pregnancies could be an indicator that this is a real risk. Unfortunately the picture here is mixed and unclear. There is a short term increase in cancer risk in women following pregnancy. However the lifetime risk of cancer is decreased with pregnancy vs no pregnancy. And further the risk of some cancers are reduced with each successive pregnancy. The only place where cancer risk and exogenous HCG has been studied is in IVF. Typically a single dose of 5000IU is used for each round of IVF. Studies of of IVF patients generally have not identified an increase in cancer risk. So not a lot of clarity. I think it makes sense to avoid HCG if you have active cancer. Outside of that there may be a risk associated with urinary derived HCG, so it comes down to individual risk tolerance. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
"Urinary-derived hCG preparations are highly carcinogenic"
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