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I use "BD" brand 31 guage x 5/16" syringes. Inserting the needle slowly it easily goes into the skin... it's the next layer of tissue that is a little more difficult to poke through but you must... once I'm through that second layer I bury that short needle all the way in and then push the plunger down. You should not feel any resistance pushing the plunger down. My Trimix script I think is above average in strength at 40/30/1 and with a fresh batch 3 or 4 units(a few drops) has me good to go. I agree that 5 units is much safer starting dose but sounds like the needle was not where it was supposed to be. Do more research and homework on Trimix injections.