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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Undecanoate split (NEBIDO/AVEED)
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<blockquote data-quote="Nelson Vergel" data-source="post: 56935" data-attributes="member: 3"><p><span style="font-size: 12px"><span style="font-family: 'Arial'">It would be an interesting experiment to inject 1 cc (333.3 mg) per month of testosterone undecanoate instead of 1000 mg every 3 months. I have not seen pharmacokinetic data on that dose. I do not think that dose will be enough, though. 500 mg per month will be more like it.</span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'">Note: Aveed has 750 mg of testosterone undecanoate. Nebido has 1000 mg.</span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><strong>Pharmacokinetics</strong></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000"><em>Absorption</em></span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000">Aveed 750 mg delivers physiologic amounts of testosterone, producing circulation testosterone concentrations that approximate normal concentrations (300-1000 ng/dL) seen in healthy men.</span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000">Testosterone esters in oil injected intramuscularly are absorbed from the lipid phase. Cleavage of the undecanoic acid side chain of Aveed by tissue esterases releases testosterone.</span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000">Following intramuscular injection of 750 mg of Aveed, serum testosterone concentrations reach a maximum after a median of </span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000">7 days (range 4 &#8211; 42 days) then slowly decline (Figure 3). Steady state serum testosterone concentration was achieved with the 3rd injection of Aveed at 14 weeks. </span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000">Figure 3 shows the mean serum total testosterone concentration-time profile during the 3rd injection interval (at steady state, 14-24 weeks) for hypogonadal men (less than 300 ng/dL) given 750 mg Aveed at initiation, at 4 weeks, and every 10 weeks thereafter. Intramuscular injection of 750 mg of Aveed generates mean steady state serum total testosterone concentrations in the normal range for 10 weeks.</span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000"></span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000">[ATTACH]2855[/ATTACH]</span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000"></span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000">As you can tell, if you want TT to remind above 500 ng/dL, you would have to inject Aveed every month or so.</span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000"></span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000"></span></span></span></p><p><span style="font-size: 12px"><span style="font-family: 'Arial'"><span style="color: #000000"></span>[ATTACH]2856[/ATTACH]</span></span><span style="color: #000000"><span style="font-size: 12px"><span style="font-family: 'Arial'"></span></span></span></p><p><span style="color: #000000"><span style="font-size: 12px"><span style="font-family: 'Arial'"></span></span></span></p><p><span style="color: #000000"><span style="font-size: 12px"><span style="font-family: 'Arial'"></span></span></span></p><p><span style="color: #000000"></span></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 56935, member: 3"] [SIZE=3][FONT=arial]It would be an interesting experiment to inject 1 cc (333.3 mg) per month of testosterone undecanoate instead of 1000 mg every 3 months. I have not seen pharmacokinetic data on that dose. I do not think that dose will be enough, though. 500 mg per month will be more like it. Note: Aveed has 750 mg of testosterone undecanoate. Nebido has 1000 mg. [B]Pharmacokinetics[/B] [COLOR=#000000][I]Absorption[/I][/COLOR] [COLOR=#000000]Aveed 750 mg delivers physiologic amounts of testosterone, producing circulation testosterone concentrations that approximate normal concentrations (300-1000 ng/dL) seen in healthy men.[/COLOR] [COLOR=#000000]Testosterone esters in oil injected intramuscularly are absorbed from the lipid phase. Cleavage of the undecanoic acid side chain of Aveed by tissue esterases releases testosterone.[/COLOR] [COLOR=#000000]Following intramuscular injection of 750 mg of Aveed, serum testosterone concentrations reach a maximum after a median of 7 days (range 4 – 42 days) then slowly decline (Figure 3). Steady state serum testosterone concentration was achieved with the 3rd injection of Aveed at 14 weeks. [/COLOR] [COLOR=#000000]Figure 3 shows the mean serum total testosterone concentration-time profile during the 3rd injection interval (at steady state, 14-24 weeks) for hypogonadal men (less than 300 ng/dL) given 750 mg Aveed at initiation, at 4 weeks, and every 10 weeks thereafter. Intramuscular injection of 750 mg of Aveed generates mean steady state serum total testosterone concentrations in the normal range for 10 weeks. [ATTACH=CONFIG]2855[/ATTACH] As you can tell, if you want TT to remind above 500 ng/dL, you would have to inject Aveed every month or so. [/COLOR][ATTACH=CONFIG]2856[/ATTACH][/FONT][/SIZE][COLOR=#000000][FONT=ArialUnicodeMS][SIZE=3][FONT=arial] [/FONT][/SIZE] [/FONT][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Undecanoate split (NEBIDO/AVEED)
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