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<blockquote data-quote="madman" data-source="post: 180102" data-attributes="member: 13851"><p>Way too high of a jump going from 125-200mg/week.</p><p></p><p>A dose increase of 20mg/week can result in a big jump in TT/FT levels.</p><p></p><p>If I were to increase my dose 10-20mg/week it will result in a 300ng/dL increase in TT.</p><p></p><p>Keep in mind that you were only injecting Sustanon 125mg once weekly and although your current TT 14.9 nmol/L (430 ng/dL) trough (7 days post-injection) level is sub-optimal that your peak TT/FT levels will be much higher earlier in the week.</p><p></p><p>The downfall of high dose once-weekly injections is that there will be a big variation between the peak--->trough level and blood levels will not be as stable throughout the week.</p><p></p><p>125mg every 5 days or increasing the overall weekly dose to 150 mg and injecting 75mg twice weekly (every 3.5 days) would be a more sensible move.</p><p></p><p>200mg once weekly is going to most likely have your peak TT/FT/e2 levels too high let alone it will drive up your hematocrit/hemoglobin.</p><p></p><p>Although symptom relief is what truly matters blood work is still critical not only to make sure blood markers are in a healthy range but more importantly minimize any potential negative side-effects as there is such a thing as too high T levels for therapeutic treatment.</p><p></p><p>On average most men can easily achieve a healthy TT/FT level using 100-150mg/week of T and yes some need slightly higher doses but in many cases, 200mg/week is rarely needed to achieve such.</p></blockquote><p></p>
[QUOTE="madman, post: 180102, member: 13851"] Way too high of a jump going from 125-200mg/week. A dose increase of 20mg/week can result in a big jump in TT/FT levels. If I were to increase my dose 10-20mg/week it will result in a 300ng/dL increase in TT. Keep in mind that you were only injecting Sustanon 125mg once weekly and although your current TT 14.9 nmol/L (430 ng/dL) trough (7 days post-injection) level is sub-optimal that your peak TT/FT levels will be much higher earlier in the week. The downfall of high dose once-weekly injections is that there will be a big variation between the peak--->trough level and blood levels will not be as stable throughout the week. 125mg every 5 days or increasing the overall weekly dose to 150 mg and injecting 75mg twice weekly (every 3.5 days) would be a more sensible move. 200mg once weekly is going to most likely have your peak TT/FT/e2 levels too high let alone it will drive up your hematocrit/hemoglobin. Although symptom relief is what truly matters blood work is still critical not only to make sure blood markers are in a healthy range but more importantly minimize any potential negative side-effects as there is such a thing as too high T levels for therapeutic treatment. On average most men can easily achieve a healthy TT/FT level using 100-150mg/week of T and yes some need slightly higher doses but in many cases, 200mg/week is rarely needed to achieve such. [/QUOTE]
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