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Health & Wellness
UDCA, NorUDCA, and TUDCA in Liver Diseases: A Review of Their Mechanisms of Action and Clinical Applications
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<blockquote data-quote="madman" data-source="post: 153635" data-attributes="member: 13851"><p><strong>Abstract </strong></p><p></p><p><span style="color: rgb(26, 188, 156)"><strong>Bile acids (BAs) are key molecules in generating bile flow, which is an essential function of the liver.</strong></span> <strong><span style="color: rgb(184, 49, 47)">In the last decades, there have been great advances in the understanding of BA physiology, and new insights have emerged regarding the role of BAs in determining cell damage and death in several liver diseases. This new knowledge has helped to better delineate the pathophysiology of cholestasis and the adaptive responses of hepatocytes to cholestatic liver injury as well as of the mechanisms of injury of biliary epithelia.</span></strong> <span style="color: rgb(44, 130, 201)"><strong>In this context, therapeutic approaches for liver diseases using hydrophilic BA (i.e., ursodeoxycholic acid, tauroursodeoxycholic, and, more recently, norursodeoxycholic acid), have been revamped. </strong></span><strong><span style="color: rgb(251, 160, 38)">In the present review, we summarize current experimental and clinical data regarding these BAs and its role in the treatment of certain liver diseases. </span></strong></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">5</span> Summary and Outlook </strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Significant advances have been made in the understanding of the beneficial effects of hydrophilic BA in the liver. </span></strong><span style="color: rgb(44, 130, 201)"><strong>Both basic science and clinical studies have either disclosed the mechanisms of action or proved the efficacy of compounds that were found to be medically useful hundreds of years ago. </strong></span><strong><span style="color: rgb(26, 188, 156)">The science of BA will continue developing, and new evidence will likely provide foundations for new, evidence based, and effective treatments for certain common and uncommon liver diseases </span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 153635, member: 13851"] [B]Abstract [/B] [COLOR=rgb(26, 188, 156)][B]Bile acids (BAs) are key molecules in generating bile flow, which is an essential function of the liver.[/B][/COLOR] [B][COLOR=rgb(184, 49, 47)]In the last decades, there have been great advances in the understanding of BA physiology, and new insights have emerged regarding the role of BAs in determining cell damage and death in several liver diseases. This new knowledge has helped to better delineate the pathophysiology of cholestasis and the adaptive responses of hepatocytes to cholestatic liver injury as well as of the mechanisms of injury of biliary epithelia.[/COLOR][/B] [COLOR=rgb(44, 130, 201)][B]In this context, therapeutic approaches for liver diseases using hydrophilic BA (i.e., ursodeoxycholic acid, tauroursodeoxycholic, and, more recently, norursodeoxycholic acid), have been revamped. [/B][/COLOR][B][COLOR=rgb(251, 160, 38)]In the present review, we summarize current experimental and clinical data regarding these BAs and its role in the treatment of certain liver diseases. [/COLOR][/B] [B][COLOR=rgb(184, 49, 47)]5[/COLOR] Summary and Outlook [/B] [B][COLOR=rgb(184, 49, 47)]Significant advances have been made in the understanding of the beneficial effects of hydrophilic BA in the liver. [/COLOR][/B][COLOR=rgb(44, 130, 201)][B]Both basic science and clinical studies have either disclosed the mechanisms of action or proved the efficacy of compounds that were found to be medically useful hundreds of years ago. [/B][/COLOR][B][COLOR=rgb(26, 188, 156)]The science of BA will continue developing, and new evidence will likely provide foundations for new, evidence based, and effective treatments for certain common and uncommon liver diseases [/COLOR][/B] [/QUOTE]
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UDCA, NorUDCA, and TUDCA in Liver Diseases: A Review of Their Mechanisms of Action and Clinical Applications
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