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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TT: 1100+ E2: 95+ on 150mg/week MWF. Sensitive/standard assay results compared.
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<blockquote data-quote="madman" data-source="post: 203806" data-attributes="member: 13851"><p><strong><em>* <u>(so I assume the sensitive FT result above converts to 34.7 pg/ml?)</u></em></strong><u>.....No, as the units are in pg/mL Quest Equilibrium Dialysis (reference range 35-155 pg/mL).</u></p><p></p><p>My mistake as I thought they were done through Quest.</p><p></p><p>Regardless the units are still in pg/mL Labcorp Equilibrium Dialysis (reference range 52-280 pg/mL).</p><p></p><p>The piss poor direct immunoassay through Labcorp reference range varies depending on age.....30-39 (reference range 8.7-25.1 pg/mL).</p><p></p><p>The direct immunoassay is known to be inaccurate and should not be used/relied upon when testing FT.</p><p></p><p>You should have ordered the Equilibrium Ultrafiltration through Labcorp which would have been much cheaper or if anything purchase the Equilibrium Dialysis or Ultrafiltration assay through Nelsons discounted labs which would be cheaper in the long run.</p><p></p><p>FT Equilibrium Dialysis assay through Labcorp is very expensive.</p><p></p><p>Keep in mind that will there not be a significant impact on body composition (muscle gains/fat loss) whether running a TT 1200 or 800.</p><p></p><p>Even then when using therapeutic doses of T the impact on muscle/strength gains will be minor when compared to using steroid doses of T (300-600 mg/week).</p><p></p><p>Although having healthy TT/FT levels will have a positive impact on muscle, fat loss, one's diet/training protocol is key let alone GENETICS will have the final say!</p><p></p><p></p><p></p><p></p><p><strong>post # 6</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-use-causing-erythrocytosis.23587/#post-202943[/URL]</p><p></p><p>When using exogenous T RBCs/hemoglobin/hematocrit will increase within the 1st month and can take up to 9-12 months to reach peak levels.</p><p></p><p>T formulation, the dose of T, genetics (polymorphism of the AR), age all play a role in the impact a trt protocol will have on blood markers (RBCs/hemoglobin/hematocrit).</p><p></p><p>Other factors such as sleep apnea, smoking can have a negative impact on hematocrit.</p><p></p><p>Injectable T has been shown to have a greater impact on increasing HCT compared to transdermal T.</p><p></p><p>3–18% with transdermal administration and up to 44% with injection.</p><p></p><p>In most cases when using injectable T <u><strong><em>high supra-physiological peaks post-injection and overall T levels (running too high TT/FT level)</em></strong></u> will have a big impact on increasing HCT.</p><p></p><p>Manipulating injection frequency by injecting more frequently using lower doses of T resulting in minimizing the peak--->trough and maintaining more stable levels may lessen the impact on HCT but it is not a given.</p><p></p><p><strong><em>As again </em></strong><em><strong>running very high TT/FT levels will have a stronger impact on driving up HCT.</strong></em></p><p></p><p>Although injectables have been shown to have a greater impact on HCT you can see even when using a transdermal formulation that maintains stable serum concentrations that <em><strong>the impact it has on HCT is DEPENDANT ON THE DOSE AND SERUM LEVEL OF T.</strong></em></p><p></p><p>Using higher doses of transdermal T and achieving higher TT/FT levels will have a great impact on HCT levels.</p><p></p><p>How high an FT level you are running is critical.</p><p></p><p>It is a given that most men on trt struggling with elevated RBCs/hemoglobin/hematocrit are running too high an FT level.</p><p></p><p>Sure some men are more sensitive than others as they may still struggle with elevated blood markers when running lower T levels but it is far from common and many may already have an underlying health issue contributing to such.</p><p></p><p>If you are struggling with such blood markers then in most cases finding the lowest FT level you can run while still maintaining the beneficial effects may very well be the solution.</p><p></p><p>Easier said than done as many men on trt tend to do better running higher-end FT levels within reason.</p><p></p><p>Mind you some are lucky and never have an issue or levels tend to stabilize over time.</p><p></p><p>Others will continue to struggle until the cows come home.</p><p></p><p>Unfortunately too many are caught up in running absurdly high trough FT levels due to the herd mentality spewed on the bro forums and gootube!</p></blockquote><p></p>
[QUOTE="madman, post: 203806, member: 13851"] [B][I]* [U](so I assume the sensitive FT result above converts to 34.7 pg/ml?)[/U][/I][/B][U].....No, as the units are in pg/mL Quest Equilibrium Dialysis (reference range 35-155 pg/mL).[/U] My mistake as I thought they were done through Quest. Regardless the units are still in pg/mL Labcorp Equilibrium Dialysis (reference range 52-280 pg/mL). The piss poor direct immunoassay through Labcorp reference range varies depending on age.....30-39 (reference range 8.7-25.1 pg/mL). The direct immunoassay is known to be inaccurate and should not be used/relied upon when testing FT. You should have ordered the Equilibrium Ultrafiltration through Labcorp which would have been much cheaper or if anything purchase the Equilibrium Dialysis or Ultrafiltration assay through Nelsons discounted labs which would be cheaper in the long run. FT Equilibrium Dialysis assay through Labcorp is very expensive. Keep in mind that will there not be a significant impact on body composition (muscle gains/fat loss) whether running a TT 1200 or 800. Even then when using therapeutic doses of T the impact on muscle/strength gains will be minor when compared to using steroid doses of T (300-600 mg/week). Although having healthy TT/FT levels will have a positive impact on muscle, fat loss, one's diet/training protocol is key let alone GENETICS will have the final say! [B]post # 6[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-use-causing-erythrocytosis.23587/#post-202943[/URL] When using exogenous T RBCs/hemoglobin/hematocrit will increase within the 1st month and can take up to 9-12 months to reach peak levels. T formulation, the dose of T, genetics (polymorphism of the AR), age all play a role in the impact a trt protocol will have on blood markers (RBCs/hemoglobin/hematocrit). Other factors such as sleep apnea, smoking can have a negative impact on hematocrit. Injectable T has been shown to have a greater impact on increasing HCT compared to transdermal T. 3–18% with transdermal administration and up to 44% with injection. In most cases when using injectable T [U][B][I]high supra-physiological peaks post-injection and overall T levels (running too high TT/FT level)[/I][/B][/U] will have a big impact on increasing HCT. Manipulating injection frequency by injecting more frequently using lower doses of T resulting in minimizing the peak--->trough and maintaining more stable levels may lessen the impact on HCT but it is not a given. [B][I]As again [/I][/B][I][B]running very high TT/FT levels will have a stronger impact on driving up HCT.[/B][/I] Although injectables have been shown to have a greater impact on HCT you can see even when using a transdermal formulation that maintains stable serum concentrations that [I][B]the impact it has on HCT is DEPENDANT ON THE DOSE AND SERUM LEVEL OF T.[/B][/I] Using higher doses of transdermal T and achieving higher TT/FT levels will have a great impact on HCT levels. How high an FT level you are running is critical. It is a given that most men on trt struggling with elevated RBCs/hemoglobin/hematocrit are running too high an FT level. Sure some men are more sensitive than others as they may still struggle with elevated blood markers when running lower T levels but it is far from common and many may already have an underlying health issue contributing to such. If you are struggling with such blood markers then in most cases finding the lowest FT level you can run while still maintaining the beneficial effects may very well be the solution. Easier said than done as many men on trt tend to do better running higher-end FT levels within reason. Mind you some are lucky and never have an issue or levels tend to stabilize over time. Others will continue to struggle until the cows come home. Unfortunately too many are caught up in running absurdly high trough FT levels due to the herd mentality spewed on the bro forums and gootube! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TT: 1100+ E2: 95+ on 150mg/week MWF. Sensitive/standard assay results compared.
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