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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TT: 1100+ E2: 95+ on 150mg/week MWF. Sensitive/standard assay results compared.
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<blockquote data-quote="madman" data-source="post: 203729" data-attributes="member: 13851"><p>Acne (genetically prone individuals) let alone higher RBCs/hematocrit/hemoglobin are due to excess FT.</p><p></p><p>If you feel great overall and are not struggling with any sides then I would say leave it be but unfortunately, your acne went from being mild--->severe.</p><p></p><p>Your hematocrit is not too high and although your estradiol is high if you were not struggling with any sides then I would not be too concerned.</p><p></p><p>You are already 11 weeks in and blood levels will have stabilized (4-6 weeks).</p><p></p><p>Chances are that you will continue to struggle with the acne due to running higher-end trough FT levels.</p><p></p><p>Although DHT can stimulate the sebaceous (oil glands) to increase in size and produce excess sebum which can lead to acne (mild/moderate/severe) in the genetically prone there is more to the story.</p><p></p><p>Androgens and activation of the AR.</p><p></p><p>Comes down to genetics, the sensitivity of the AR to androgens, and the sensitivity of the skin/hair follicles to DHT.</p><p></p><p>Excess e2 can contribute to inflammation in some.</p><p></p><p>You could most likely clear up the acne by bringing down your trough FT level which will also lower estradiol and you may very well feel just as good overall minus the sides otherwise you will need to look into treating your acne.</p><p></p><p>Highly doubtful manipulating your diet will clear up your acne as it is due to excess androgens/FT.....hormonally induced acne!</p><p></p><p></p><p></p><p></p><p><strong>DHT and Androgenic Side Effects</strong></p><p></p><p>"In some regards, this local potentiation of testosterone's activity may be unwelcome, as higher androgenic activity in certain tissues may produce a number of undesirable side effects. <strong>Acne, for example, is often triggered by dihydrotestosterone activity in the sebaceous glands, and the local formation of dihydrotestosterone in the scalp is typically blamed for triggering male pattern hair loss. You should know that it is a terrible misconception among bodybuilders that dihydrotestosterone is an isolated culprit when it comes to these side effects.</strong> <strong><u>All anabolic/androgenic steroids exert their activities, both anabolic and androgenic, through the same cellular androgen receptor</u>"</strong></p><p><strong></strong></p><p><strong>"Dihydrotestosterone is no different than any other steroid except that it is a more potent activator of this receptor than most, and can be formed locally in certain androgen-sensitive tissues. <u>All steroids can cause androgenic side effects in direct relation to their affinity for this receptor, and DHT has no known unique ability in this regard</u>"</strong></p><p></p><p>The main point to keep in mind regarding acne or hair loss (genetically prone individuals).....is that DHT is not the sole contributor and it is the general activation of the AR that is responsible.</p><p></p><p>You are injecting 150 mg T/week split M/W/F</p><p></p><p>As you can see on the first set of labs the most accurate assays were used for TT (LC/MS-MS) and FT (Equilibrium Dialysis).</p><p></p><p><em><strong>TT 1141.2 ng/dl (LC/MS-MS)</strong></em></p><p><strong><em>FT 347 (ordered the sensitive assay, labeled as MS/Dialysis? Mentions LC/MS-MS in the details, units not listed)</em></strong></p><p><strong><em>E2 97.1 pg/ml (sensitive, details state LC/MS-MS)</em></strong></p><p>SHBG 25.1 nmol/L</p><p>HCT 49.6%</p><p></p><p></p><p>You are hitting a high-end TT 1141 ng/dL and with an SHBG 25 nmol/L, your FT level is and would be very high 347 pg/mL (reference range 35-155 pg/mL).</p><p></p><p>Keep in mind that if your labs were done at true trough then peak TT/FT/estradiol levels will be higher.</p><p></p><p>Regarding your second set of labs, you tested FT using the piss poor direct immunoassay which was pointless as it is not an accurate testing method.</p><p></p><p><em><strong>TT 1251 (standard)</strong></em></p><p><strong><em>FT 35.8 pg/ml <u>(so I assume the sensitive FT result above converts to 34.7 pg/ml?)</u></em></strong></p><p><em><strong>E2 95.1 pg/ml (Roche ECLIA)</strong></em></p><p></p><p></p><p><strong><em>* <u>(so I assume the sensitive FT result above converts to 34.7 pg/ml?)</u></em></strong><u>.....No, as the units are in pg/mL Quest Equilibrium Dialysis (reference range 35-155 pg/mL).</u></p><p></p><p>Two completely different assays (scales/reference ranges) comparing the piss poor direct immunoassay to the most accurate assays (Equilibrium Dialysis or Ultrafiltration) is a waste of time!</p><p></p><p>Again the only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best) along with TT (LC/MS-MS).</p><p></p><p>Which you clearly did on your 1st set of labs!</p></blockquote><p></p>
[QUOTE="madman, post: 203729, member: 13851"] Acne (genetically prone individuals) let alone higher RBCs/hematocrit/hemoglobin are due to excess FT. If you feel great overall and are not struggling with any sides then I would say leave it be but unfortunately, your acne went from being mild--->severe. Your hematocrit is not too high and although your estradiol is high if you were not struggling with any sides then I would not be too concerned. You are already 11 weeks in and blood levels will have stabilized (4-6 weeks). Chances are that you will continue to struggle with the acne due to running higher-end trough FT levels. Although DHT can stimulate the sebaceous (oil glands) to increase in size and produce excess sebum which can lead to acne (mild/moderate/severe) in the genetically prone there is more to the story. Androgens and activation of the AR. Comes down to genetics, the sensitivity of the AR to androgens, and the sensitivity of the skin/hair follicles to DHT. Excess e2 can contribute to inflammation in some. You could most likely clear up the acne by bringing down your trough FT level which will also lower estradiol and you may very well feel just as good overall minus the sides otherwise you will need to look into treating your acne. Highly doubtful manipulating your diet will clear up your acne as it is due to excess androgens/FT.....hormonally induced acne! [B]DHT and Androgenic Side Effects[/B] "In some regards, this local potentiation of testosterone's activity may be unwelcome, as higher androgenic activity in certain tissues may produce a number of undesirable side effects. [B]Acne, for example, is often triggered by dihydrotestosterone activity in the sebaceous glands, and the local formation of dihydrotestosterone in the scalp is typically blamed for triggering male pattern hair loss. You should know that it is a terrible misconception among bodybuilders that dihydrotestosterone is an isolated culprit when it comes to these side effects.[/B] [B][U]All anabolic/androgenic steroids exert their activities, both anabolic and androgenic, through the same cellular androgen receptor[/U]" "Dihydrotestosterone is no different than any other steroid except that it is a more potent activator of this receptor than most, and can be formed locally in certain androgen-sensitive tissues. [U]All steroids can cause androgenic side effects in direct relation to their affinity for this receptor, and DHT has no known unique ability in this regard[/U]"[/B] The main point to keep in mind regarding acne or hair loss (genetically prone individuals).....is that DHT is not the sole contributor and it is the general activation of the AR that is responsible. You are injecting 150 mg T/week split M/W/F As you can see on the first set of labs the most accurate assays were used for TT (LC/MS-MS) and FT (Equilibrium Dialysis). [I][B]TT 1141.2 ng/dl (LC/MS-MS)[/B][/I] [B][I]FT 347 (ordered the sensitive assay, labeled as MS/Dialysis? Mentions LC/MS-MS in the details, units not listed) E2 97.1 pg/ml (sensitive, details state LC/MS-MS)[/I][/B] SHBG 25.1 nmol/L HCT 49.6% You are hitting a high-end TT 1141 ng/dL and with an SHBG 25 nmol/L, your FT level is and would be very high 347 pg/mL (reference range 35-155 pg/mL). Keep in mind that if your labs were done at true trough then peak TT/FT/estradiol levels will be higher. Regarding your second set of labs, you tested FT using the piss poor direct immunoassay which was pointless as it is not an accurate testing method. [I][B]TT 1251 (standard)[/B][/I] [B][I]FT 35.8 pg/ml [U](so I assume the sensitive FT result above converts to 34.7 pg/ml?)[/U][/I][/B] [I][B]E2 95.1 pg/ml (Roche ECLIA)[/B][/I] [B][I]* [U](so I assume the sensitive FT result above converts to 34.7 pg/ml?)[/U][/I][/B][U].....No, as the units are in pg/mL Quest Equilibrium Dialysis (reference range 35-155 pg/mL).[/U] Two completely different assays (scales/reference ranges) comparing the piss poor direct immunoassay to the most accurate assays (Equilibrium Dialysis or Ultrafiltration) is a waste of time! Again the only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best) along with TT (LC/MS-MS). Which you clearly did on your 1st set of labs! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TT: 1100+ E2: 95+ on 150mg/week MWF. Sensitive/standard assay results compared.
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