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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
TSH Labs / Hypothyroidism
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<blockquote data-quote="torrential" data-source="post: 136014" data-attributes="member: 2752"><p>Vince Carter, this is an excellent question.</p><p></p><p>Buried in my brain is a piece of info that I hardly ever see mentioned. Iodine is carried throughout the body by the Sodium Iodide Symporter, abbreviated NIS (N for Sodium/Na, I for Iodine, S for Symporter). When there is iodine available to transport, the body creates the NIS protein to grab it and take it to where where it's needed. The carrier of NIS? Thyroid Stimulating Hormone. When supplementing iodine TSH will rise, sometimes significantly, unrelated to levels of the thyroid hormones we are concerned with here.</p><p></p><p>This isn't the best info but I didn't want to show up empty handed</p><p></p><p><a href="https://en.wikipedia.org/wiki/Sodium-iodide_symporter" target="_blank">Sodium-iodide symporter - Wikipedia</a></p><p></p><p>...<em>Iodine uptake is a result of an <a href="https://en.wikipedia.org/wiki/Active_transport" target="_blank">active transport</a> mechanism mediated by the NIS protein, which is found in the <a href="https://en.wikipedia.org/wiki/Basolateral_membrane#Membrane_polarity" target="_blank">basolateral membrane</a> of thyroid follicular cells. </em></p><p>blah blah blah</p><p><em>...Note that the regulation of NIS expression in thyroid is done by the <a href="https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone" target="_blank">thyroid-stimulating hormone</a> (TSH) ...</em></p><p></p><p>Personal example: Years ago Dr. John <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite3" alt=":(" title="Frown :(" loading="lazy" data-shortname=":(" /> diagnosed me as subclinically hypothroid. Started me on a full Brownstein iodine protocol, titrated doses from trace up to 50mg/day and back to 12.5mg/day over four months. TSH shot through the roof, as high as 7.85 at one point, while T3, T4, etc, inched slowly towards optimization.</p><p></p><p>It's common to see well intentioned and otherwise well informed folks tell us "Iodine causes hypothrodism because when you take it TSH goes up." As we see in our discussions of thyroid health and mentioned by several on this thread, TSH alone cannot be used for diagnosis of thyroid conditions. Consideration of its role in the NIS is yet another reason why this is true.</p></blockquote><p></p>
[QUOTE="torrential, post: 136014, member: 2752"] Vince Carter, this is an excellent question. Buried in my brain is a piece of info that I hardly ever see mentioned. Iodine is carried throughout the body by the Sodium Iodide Symporter, abbreviated NIS (N for Sodium/Na, I for Iodine, S for Symporter). When there is iodine available to transport, the body creates the NIS protein to grab it and take it to where where it's needed. The carrier of NIS? Thyroid Stimulating Hormone. When supplementing iodine TSH will rise, sometimes significantly, unrelated to levels of the thyroid hormones we are concerned with here. This isn't the best info but I didn't want to show up empty handed [URL='https://en.wikipedia.org/wiki/Sodium-iodide_symporter']Sodium-iodide symporter - Wikipedia[/URL] ...[I]Iodine uptake is a result of an [URL='https://en.wikipedia.org/wiki/Active_transport']active transport[/URL] mechanism mediated by the NIS protein, which is found in the [URL='https://en.wikipedia.org/wiki/Basolateral_membrane#Membrane_polarity']basolateral membrane[/URL] of thyroid follicular cells. [/I] blah blah blah [I]...Note that the regulation of NIS expression in thyroid is done by the [URL='https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone']thyroid-stimulating hormone[/URL] (TSH) ...[/I] Personal example: Years ago Dr. John :( diagnosed me as subclinically hypothroid. Started me on a full Brownstein iodine protocol, titrated doses from trace up to 50mg/day and back to 12.5mg/day over four months. TSH shot through the roof, as high as 7.85 at one point, while T3, T4, etc, inched slowly towards optimization. It's common to see well intentioned and otherwise well informed folks tell us "Iodine causes hypothrodism because when you take it TSH goes up." As we see in our discussions of thyroid health and mentioned by several on this thread, TSH alone cannot be used for diagnosis of thyroid conditions. Consideration of its role in the NIS is yet another reason why this is true. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
TSH Labs / Hypothyroidism
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