Way too low a dose!
More like 600-1200 mg.
Even then would not waste my time with pellets.
[URL unfurl="true"]https://www.excelmale.com/threads/pharmacology-of-testosterone-pellet-implants.29906/[/URL]
5 Absorption
5.1 Mechanism of absorption
Absorption of testosterone from the pellets occurs via an uniform erosion of the pellet's surface. Empirical evidence for this includes the observation that pellets recovered up to 3 months after implantation retain their cylindrical shape (Fig. 2). A mathematical model incorporating a uniform rate of surface erosion (Forbes 1941) fits data available from direct measurements of release rate well (Bishop and Folley 1951). Direct testing of the importance of pellet surface area for absorption is difficult since in the two pellet sizes available, surface area and dose are mostly confounded due to the common cylindrical shape and diameter. In order to examine for evidence of an effect of pellet surface area independent of dose, we compared the effects of 3 x 200 mg with 6 x 100 mg pellet implants which controlled for total dose (600 mg) while allowing for a 16% difference in initial surface area. The regimen with greater initial surface area produced higher free testosterone levels and greater gonadotropin suppression in the first (but not the second) 3 months. This evidence supports the surface area-limited release mechanism. Deviations from the surface erosion model can be expected if the absorbing area enlarges unpredictably due to surface irregularities, pitting or fragmentation of the pellet or if absorption via matrix-controlled diffusion supervenes as the pellet size decreases. While pellet geometry (especially surface area) appears the rate-limiting factor in testosterone absorption from subdermal pellets (Emmens 1941), additional factors are also important. These include (i) the chemistry of the steroid especially its hydrophobicity, (ii) pellet hardness, smoothness and size, (iii) the site of implantation, its local blood flow and trauma and (iv) the tissue reaction and encasing of the pellet (Foss 1939; Emmens 1941;Forbes 1941; Bishop and Folley 1951). Circulating sex steroid levels, however,appear not to be important (Emmens, 1941). Few of these factors have been systematically tested in humans and the importance of pellet geometry and site of implantation in regulating testosterone release rate warrant further evaluation.
5.2 Kinetics of absorption
Absorption rate of testosterone from pellets appears to be limited by the exposed pellet surface area from which the steroid leeches out into the extracellular fluid. Empirical calculation of the effective testosterone release rate can be made both directly from measurement of residue in extruded pellets and indirectly from the percent absorbed-time plots and these independent estimates are in reasonable agreement. A direct estimate of absorption rate of 1.5 (95% c.L. 1.4-1.7) mg/ dayl 200 mg pellet was derived from remnants of six 200 mg pellets which exhibited linear rate of release with time up to 92 days (Fig.3). An indirect, corroborative estimate was obtained independently from the percent absorbed-time plots which, being nearly linear (Fig.4), provided evidence of a very good approximation to ideal zero-order release for either total or free testosterone. These curves provided an estimate of 2.5 months for the effective half-time of absorption and calculated testosterone release rate of 0.65 mg/day/l00 mg pellet. Neither the size nor number of pellets influenced the rate of testosterone absorption. These calculations are comparable with the only other available estimate of 1.1 mg/day/l00 mg pellet from fused testosterone pellets removed at intervals after implantation in the antecubital or subscapular region (Bishop and Folley1951). The 41 % lower release rate of fused pellets implanted in the anterior abdominal wall (our study) despite a 66% greater initial surface area suggest important site-specific release characteristics.
The present estimates of testosterone release rate are also consistent with indirect estimates that can be calculated (much less accurately) from increments incirculating testosterone produced by implantation of single 100 mg and 200 mg pellets in women (Thorn et al. 1981; Dewis et al. 1986) after correcting for gender differences in testosterone clearance rates (Southren et al. 1968; Gandy 1977).
6 Bioavailability
The bioavailability of testosterone from subdermal pellets is virtually complete as calculated from the net appearance of testosterone in the bloodstream. The net release of testosterone in the circulation can be calculated from the time-course of testosterone levels if the whole body testosterone metabolic clearance rate is known and remains constant throughout the study. Since SHBG levels, which are the major determinant of testosterone metabolic clearance rate (Vermeulen et al.1969), remain unaltered following pellet implantation it is reasonable to assume a constant testosterone clearance rate (mean 540 l/sq m/day [Southren et al.1968; Gandy 1977]) throughout the life-span of a pellet implant. Such a calculation indicates that by 6 months virtually all the testosterone from the 600 mg pellet and about 90% of that in the 1200 mg pellets was absorbed. Consistent with the near complete bioavailability, net testosterone release is closely correlated with pellet dose (r=0.999) so that a 6 x 200 mg dose regimen gives twice that of either 6x 1 00 mg or 3 x 200 mg regimen, the latter two of which gave very similar net release of testosterone. This high bioavailability is not unexpected for a steroid administered parenterally and absorbed into the systemic circulation avoiding first-pass hepatic inactivation.
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