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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT with or without HCG and Ai
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<blockquote data-quote="Cataceous" data-source="post: 152144" data-attributes="member: 38109"><p>You neglect the important difference stated between these imaginary tubs and real tubs: these tubs can never fully empty because the flow rate out is proportional to how much is in them and to the drain sizes. So the lower the level the slower they drain. This is how things work in the body: the clearance rate is proportional to concentration.</p><p></p><p>The other important assumption is that the lower drain is always much larger than the upper drain. This is also physiological, as the half-life of testosterone in serum is on the order of minutes, whereas the injected depot is supplying testosterone with a half-life of days. Under these conditions the changes in the lower drain size change the lower tub water level proportionally, but they don't change the flow rate out of the lower drain, which must end up matching the flow rate in from the upper drain; if you suddenly halve the lower drain size then the water level rises to double where it was and the outflow again matches the inflow.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 152144, member: 38109"] You neglect the important difference stated between these imaginary tubs and real tubs: these tubs can never fully empty because the flow rate out is proportional to how much is in them and to the drain sizes. So the lower the level the slower they drain. This is how things work in the body: the clearance rate is proportional to concentration. The other important assumption is that the lower drain is always much larger than the upper drain. This is also physiological, as the half-life of testosterone in serum is on the order of minutes, whereas the injected depot is supplying testosterone with a half-life of days. Under these conditions the changes in the lower drain size change the lower tub water level proportionally, but they don't change the flow rate out of the lower drain, which must end up matching the flow rate in from the upper drain; if you suddenly halve the lower drain size then the water level rises to double where it was and the outflow again matches the inflow. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT with or without HCG and Ai
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