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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT with or without HCG and Ai
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<blockquote data-quote="Cataceous" data-source="post: 151822" data-attributes="member: 38109"><p>Excess excretion is expected if the low-SHBG guy is dosed so that his total serum testosterone matches the high-SHBG guy. In my previous example, if the guy with an SHBG of 10 nmol/L has his testosterone dose doubled so that his serum testosterone matches the 1,000 ng/dL of the high-SHBG guy, then his excretion rate is doubled—as a result of doubled free testosterone.</p><p></p><p>I'd like to see the evidence for higher peaks and lower troughs in free T. If free T is roughly linear in T then it's claiming a shorter apparent half-life, which isn't possible unless something really unusual is happening with the non-SHBG-related metabolic clearance rate of testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 151822, member: 38109"] Excess excretion is expected if the low-SHBG guy is dosed so that his total serum testosterone matches the high-SHBG guy. In my previous example, if the guy with an SHBG of 10 nmol/L has his testosterone dose doubled so that his serum testosterone matches the 1,000 ng/dL of the high-SHBG guy, then his excretion rate is doubled—as a result of doubled free testosterone. I'd like to see the evidence for higher peaks and lower troughs in free T. If free T is roughly linear in T then it's claiming a shorter apparent half-life, which isn't possible unless something really unusual is happening with the non-SHBG-related metabolic clearance rate of testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT with or without HCG and Ai
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