ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT with or without HCG and Ai
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Blackhawk" data-source="post: 151777" data-attributes="member: 16042"><p>Once T is cleaved from the ester it either becomes free T or is bound to SHBG or Albumin.</p><p></p><p>Free T is very short acting and is used up rapidly.</p><p></p><p>Guys with low SHBG have much more essentially released into the system as free T which is used up rapidly and also rapidly excreted in urine if there is excess not bound to SHBG. These guys essentially burn up the supply faster and levels subsequently crash much faster, so smaller more frequent doses are appropriate to help keep levels more stable rather than running out after 2-3 days and crashing before the next dose. In terms of numbers, some of the guys on this forum have very low SHBG in the teens.</p><p></p><p></p><p>T bound to SHBG remains in the body much longer.</p><p></p><p>More SHBG means you bind up more T and it is retained in the body over a longer time period. As such, guys who have high SHBG tend to need larger cumulative total dose injecting T to achieve good Free T levels since so much is bound by SHBG. They tend to have lower Free T in relation to total T. It is kind of like there is a better long term storage system in place with higher SHBG, and this man does not burn up the available free T as fast. However, some men with higher SHBG like me actually also do better on more frequent dosing as well. For me theoretically it helps reduce estrogen by taking smaller more frequent doses compared to larger less frequent doses. My SHBG is currently ~52 which is high but not radically so. It can reach quite a bit higher in some men.</p><p></p><p></p><p>The bottom line is larger every other week or weekly doses create a "roller coaster" effect where Free T trough level is too low to feel good. The half life of T is about 8 days which means you lose close to half the amount of T you inject in about a week. 50% lower level can cause ill effects. Low SHBG guys burn up the Free T even faster and some need every day dosing to feel OK.</p></blockquote><p></p>
[QUOTE="Blackhawk, post: 151777, member: 16042"] Once T is cleaved from the ester it either becomes free T or is bound to SHBG or Albumin. Free T is very short acting and is used up rapidly. Guys with low SHBG have much more essentially released into the system as free T which is used up rapidly and also rapidly excreted in urine if there is excess not bound to SHBG. These guys essentially burn up the supply faster and levels subsequently crash much faster, so smaller more frequent doses are appropriate to help keep levels more stable rather than running out after 2-3 days and crashing before the next dose. In terms of numbers, some of the guys on this forum have very low SHBG in the teens. T bound to SHBG remains in the body much longer. More SHBG means you bind up more T and it is retained in the body over a longer time period. As such, guys who have high SHBG tend to need larger cumulative total dose injecting T to achieve good Free T levels since so much is bound by SHBG. They tend to have lower Free T in relation to total T. It is kind of like there is a better long term storage system in place with higher SHBG, and this man does not burn up the available free T as fast. However, some men with higher SHBG like me actually also do better on more frequent dosing as well. For me theoretically it helps reduce estrogen by taking smaller more frequent doses compared to larger less frequent doses. My SHBG is currently ~52 which is high but not radically so. It can reach quite a bit higher in some men. The bottom line is larger every other week or weekly doses create a "roller coaster" effect where Free T trough level is too low to feel good. The half life of T is about 8 days which means you lose close to half the amount of T you inject in about a week. 50% lower level can cause ill effects. Low SHBG guys burn up the Free T even faster and some need every day dosing to feel OK. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT with or without HCG and Ai
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top