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I can attest that since I started TRT over 9 yrs ago it's having a negative effect on mood, sleep, memory, motivation, cognitive, etc... Looking at past labs I noticed pre-trt that my SHBG was mid-range of reference for labcorp and now it is bottom 5% of said reference which is obviously good for use of free test, etc.. However, from what I researched is that low SHBG also correlates to low/sluggish thyroid. Pre-Trt my FT4 levels was mid-range of labcorp reference range with FT3 at top 80%.. now my FT4 is bottom 10% of said range... I have researched that FT4 crosses the blood brain barrier and is responsible for cognitive/brain functions where as FT3 is for energy/metabolism, etc... At this time I started NDT (Armour Thryoid) and Im going to see if that will increase my Ft4...

[QUOTE="BillyJ03z, post: 136444, member: 17759"] I can attest that since I started TRT over 9 yrs ago it's having a negative effect on mood, sleep, memory, motivation, cognitive, etc... Looking at past labs I noticed pre-trt that my SHBG was mid-range of reference for labcorp and now it is bottom 5% of said reference which is obviously good for use of free test, etc.. However, from what I researched is that low SHBG also correlates to low/sluggish thyroid. Pre-Trt my FT4 levels was mid-range of labcorp reference range with FT3 at top 80%.. now my FT4 is bottom 10% of said range... I have researched that FT4 crosses the blood brain barrier and is responsible for cognitive/brain functions where as FT3 is for energy/metabolism, etc... At this time I started NDT (Armour Thryoid) and Im going to see if that will increase my Ft4... [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038