I think I know the timeline you are talking about, but that only addresses sexual and physical aspects, not cognitive aspects.

How do we explain the fact that I never had these problems before TRT? Something about my body chemistry is certainly "off."  I've been on Zoloft for most of the past decade and my periods of greatest mental clarity have been on Zoloft. Does testosterone cypionate interact with Zoloft?

Ever since TRT, I have had constant cognitive difficulties. Some days are worse than others. Today happens to be worse than yesterday, which was worse than the day prior. My cognitive function is so poor, I will waste most of my day off being unproductive.

I never struggled in the gym on Zoloft. These days I take a large amount of preworkout just to have the motivation to complete a workout. While I may have put on some muscle, it is very hard when I don't have the muscle energy needed to push myself. I feel as though my ATP is not there.

In any case, there has to be a biochemical explanation for my muscle weakness, and I hope someone can answer that. Preworkouts before TRT gave me insane energy with a standard portion. On TRT they either barely work, or work moderately, even taking up to 1.5-2 times the portion size. I haven't abused preworkouts since 2012 and the only reason I use them since going on TRT is because I simply don't have the drive or motivation to go to the gym and push through a workout.

The most common responses I have received about my complaints are that I haven't been on TRT long enough, or that Zoloft is now causing all of these side effects it never had before. First thing tomorrow I will schedule an appointment so that I can switch to wellbutrin. What if I still don't see results? Are we going to blame wellbutrin?

I hope Dr. Saya comments.