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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
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<blockquote data-quote="madman" data-source="post: 157669" data-attributes="member: 13851"><p><span style="color: rgb(44, 130, 201)"><strong>Doctor wants me around 30 free T, can I ever get there with such a high SHBG count? What else can I do to try lowering SHBG?</strong></span></p><p></p><p>Unfortunately the testing method you had done for free testosterone the piss poor direct immunoassay is inaccurate.....let alone tends to underestimate FT levels when compared to the gold standard Equilibrium Dialysis.</p><p></p><p>If you truly want to know where your FT levels sit on such protocol (T dose/injection frequency) than you would need to use the gold standard Equilibrium Dialysis or Ultrafiltration (next best) or simply use the newer calculated TruT method which has been shown to be on par with results obtained by the gold standard Equilibrium Dialysis.</p><p></p><p>It is available online to the general public for free....<a href="https://tru-t.org/" target="_blank"><strong>TruT Free Testosterone Calculator by FPT</strong></a></p><p>Using the newer calculated TruT method.....if we take your TT 960 ng/dL, SHBG 56.7 nmol/L, Albumin 4.3 g/dL (mean) than your FT is 31.33 ng/dL (top of the reference range of 16-31 ng/dL)..[ATTACH=full]8202[/ATTACH]</p><p></p><p></p><p>Your FT levels are already in the 30 ng/dL range and do understand that is at trough and seeing as you are injecting twice weekly (every 3.5 days) than your peak will be much higher.</p><p></p><p>As you can see even with having a higher SHBG of 56.7 nmol/L having a TT close to 1000 ng/dL puts your FT at the top end of the reference range and that is at trough.</p><p></p><p>Most still need to understand that due to the newer research/understanding of SHBG:T binding that even in cases of men with higher SHBG extremely high TT levels are not needed in order to achieve a healthy FT level.</p><p></p><p>Again your FT levels are much higher than you think!</p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(44, 130, 201)">*</span></strong><span style="color: rgb(44, 130, 201)">highlighted in blue- <strong>refer to the new Multi-step Dynamic Binding Model with Complex Allostery (TruT calculated)</strong> </span></p><p></p><p><strong><span style="color: rgb(26, 188, 156)">*</span></strong><span style="color: rgb(26, 188, 156)"> highlighted in green- <strong>refer to</strong> <strong>the linear law-of-mass-action model/equation Vermueulen</strong> <strong>(cFTV)</strong> </span></p><p></p><p></p><p><strong>[0387]</strong> <strong><span style="color: rgb(184, 49, 47)">Relation between Percent FT with Total Testosterone and SHBG.</span> </strong><span style="color: rgb(251, 160, 38)"><strong>Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations.</strong> </span><span style="color: rgb(26, 188, 156)"><strong>In contrast, the Vermeulen's equation suggests a negative relation between percent FT and total testosterone.</strong></span><strong> <span style="color: rgb(44, 130, 201)">Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline</span></strong> <strong><span style="color: rgb(26, 188, 156)">in contrast to the marked decline in percent FT calculated using Vermeulen's equation. </span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 157669, member: 13851"] [COLOR=rgb(44, 130, 201)][B]Doctor wants me around 30 free T, can I ever get there with such a high SHBG count? What else can I do to try lowering SHBG?[/B][/COLOR] Unfortunately the testing method you had done for free testosterone the piss poor direct immunoassay is inaccurate.....let alone tends to underestimate FT levels when compared to the gold standard Equilibrium Dialysis. If you truly want to know where your FT levels sit on such protocol (T dose/injection frequency) than you would need to use the gold standard Equilibrium Dialysis or Ultrafiltration (next best) or simply use the newer calculated TruT method which has been shown to be on par with results obtained by the gold standard Equilibrium Dialysis. It is available online to the general public for free....[URL='https://tru-t.org/'][B]TruT Free Testosterone Calculator by FPT[/B][/URL] Using the newer calculated TruT method.....if we take your TT 960 ng/dL, SHBG 56.7 nmol/L, Albumin 4.3 g/dL (mean) than your FT is 31.33 ng/dL (top of the reference range of 16-31 ng/dL)..[ATTACH=full]8202[/ATTACH] Your FT levels are already in the 30 ng/dL range and do understand that is at trough and seeing as you are injecting twice weekly (every 3.5 days) than your peak will be much higher. As you can see even with having a higher SHBG of 56.7 nmol/L having a TT close to 1000 ng/dL puts your FT at the top end of the reference range and that is at trough. Most still need to understand that due to the newer research/understanding of SHBG:T binding that even in cases of men with higher SHBG extremely high TT levels are not needed in order to achieve a healthy FT level. Again your FT levels are much higher than you think! [B][COLOR=rgb(44, 130, 201)]*[/COLOR][/B][COLOR=rgb(44, 130, 201)]highlighted in blue- [B]refer to the new Multi-step Dynamic Binding Model with Complex Allostery (TruT calculated)[/B] [/COLOR] [B][COLOR=rgb(26, 188, 156)]*[/COLOR][/B][COLOR=rgb(26, 188, 156)] highlighted in green- [B]refer to[/B] [B]the linear law-of-mass-action model/equation Vermueulen[/B] [B](cFTV)[/B] [/COLOR] [B][0387][/B] [B][COLOR=rgb(184, 49, 47)]Relation between Percent FT with Total Testosterone and SHBG.[/COLOR] [/B][COLOR=rgb(251, 160, 38)][B]Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated.[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations.[/B] [/COLOR][COLOR=rgb(26, 188, 156)][B]In contrast, the Vermeulen's equation suggests a negative relation between percent FT and total testosterone.[/B][/COLOR][B] [COLOR=rgb(44, 130, 201)]Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline[/COLOR][/B] [B][COLOR=rgb(26, 188, 156)]in contrast to the marked decline in percent FT calculated using Vermeulen's equation. [/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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