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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
TRT to Supraphysiological Levels for Body Building
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<blockquote data-quote="DS3" data-source="post: 216897" data-attributes="member: 18514"><p>Tremendous effort in this. Despite being on opposite sides of a position, your research is impressive.</p><p></p><p>Looking at the results and your commentary, one would have to question at what level of testosterone does long-term exposure create toxic effects. For the thought provocation, I thank you.</p><p></p><p>The results are interesting. The R2 of testosterone alone is decent. However, as you point out, the results indicate that doses of 100 ng per week or less create toxic effects over long-term exposure. Which is perhaps, as noted, a result of rats being more sensitive to testosterone exposure even at lower doses. That is, in fact, the piece that really creates pause and causes one to think: If toxic effects in rats are seen at the equivalent of therapeutic doses for humans, then is that an indication that even doses under 100 mg per week are potentially toxic? Or, is the sensitivity of wistar rats incomparable to humans, leaving the transferability of results to humans highly questionable? (Questionable not in the sense that there is no dose of testosterone that over long-term exposure exerts toxic effects, but rather, is the dosage as low as these studies would indicate?)</p></blockquote><p></p>
[QUOTE="DS3, post: 216897, member: 18514"] Tremendous effort in this. Despite being on opposite sides of a position, your research is impressive. Looking at the results and your commentary, one would have to question at what level of testosterone does long-term exposure create toxic effects. For the thought provocation, I thank you. The results are interesting. The R2 of testosterone alone is decent. However, as you point out, the results indicate that doses of 100 ng per week or less create toxic effects over long-term exposure. Which is perhaps, as noted, a result of rats being more sensitive to testosterone exposure even at lower doses. That is, in fact, the piece that really creates pause and causes one to think: If toxic effects in rats are seen at the equivalent of therapeutic doses for humans, then is that an indication that even doses under 100 mg per week are potentially toxic? Or, is the sensitivity of wistar rats incomparable to humans, leaving the transferability of results to humans highly questionable? (Questionable not in the sense that there is no dose of testosterone that over long-term exposure exerts toxic effects, but rather, is the dosage as low as these studies would indicate?) [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
TRT to Supraphysiological Levels for Body Building
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