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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
TRT to Supraphysiological Levels for Body Building
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<blockquote data-quote="Nelson Vergel" data-source="post: 216212" data-attributes="member: 3"><p>Yes, it is this one:</p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/responses-of-different-doses-of-testosterone-injections-on-body-composition-strength-etc.2125/[/URL]</p><p></p><p>Bhasin did one using 600 mg/week for 10 weeks.</p><p></p><p>[URL unfurl="true"]https://www.nejm.org/doi/full/10.1056/nejm199607043350101[/URL]</p><p></p><p>"We randomly assigned 43 normal men to one of four groups: placebo with no exercise, testosterone with no exercise, placebo plus exercise, and testosterone plus exercise. The men received injections of 600 mg of testosterone enanthate or placebo weekly for 10 weeks. The men in the exercise groups performed standardized weight-lifting exercises three times weekly. Before and after the treatment period, fat-free mass was determined by underwater weighing, muscle size was measured by magnetic resonance imaging, and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively."</p><p></p><p>[ATTACH=full]19292[/ATTACH]</p><p></p><p></p><p>The dose dependency of the action of testosterone on fat-free mass and protein synthesis has not been well studied. Forbes<a href="https://www.nejm.org/doi/full/10.1056/nejm199607043350101#" target="_blank">39</a> proposed a single dose–response curve extending from the hypogonadal to the supraphysiologic range. Others have suggested that there may be two dose–response curves: one in the hypogonadal range, with maximal responses corresponding to the serum testosterone concentrations at the lower end of the range in normal men, and the second in the supraphysiologic range, presumably representing a separate mechanism of action — that is, a pathway of independent androgen receptors.<a href="https://www.nejm.org/doi/full/10.1056/nejm199607043350101#" target="_blank">1,40</a></p><p></p><p><strong>Supraphysiologic doses of testosterone, with or without exercise, did not increase the occurrence of angry behavior by these carefully selected men in the controlled setting of this experiment. Our results, however, do not preclude the possibility that still higher doses of multiple steroids may provoke angry behavior in men with preexisting psychiatric or behavioral problems.</strong></p><p></p><p>Our results in no way justify the use of anabolic–androgenic steroids in sports, because, with extended use, such drugs have potentially serious adverse effects on the cardiovascular system, prostate, lipid metabolism, and insulin sensitivity. Moreover, the use of any performance-enhancing agent in sports raises serious ethical issues. Our findings do, however, raise the possibility that the short-term administration of androgens may have beneficial effects in immobilized patients, during space travel, and in patients with cancer-related cachexia, disease caused by the human immunodeficiency virus, or other chronic wasting disorders.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 216212, member: 3"] Yes, it is this one: [URL unfurl="true"]https://www.excelmale.com/forum/threads/responses-of-different-doses-of-testosterone-injections-on-body-composition-strength-etc.2125/[/URL] Bhasin did one using 600 mg/week for 10 weeks. [URL unfurl="true"]https://www.nejm.org/doi/full/10.1056/nejm199607043350101[/URL] "We randomly assigned 43 normal men to one of four groups: placebo with no exercise, testosterone with no exercise, placebo plus exercise, and testosterone plus exercise. The men received injections of 600 mg of testosterone enanthate or placebo weekly for 10 weeks. The men in the exercise groups performed standardized weight-lifting exercises three times weekly. Before and after the treatment period, fat-free mass was determined by underwater weighing, muscle size was measured by magnetic resonance imaging, and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively." [ATTACH type="full" alt="high dose testosterone body composition and strength.jpg"]19292[/ATTACH] The dose dependency of the action of testosterone on fat-free mass and protein synthesis has not been well studied. Forbes[URL='https://www.nejm.org/doi/full/10.1056/nejm199607043350101#']39[/URL] proposed a single dose–response curve extending from the hypogonadal to the supraphysiologic range. Others have suggested that there may be two dose–response curves: one in the hypogonadal range, with maximal responses corresponding to the serum testosterone concentrations at the lower end of the range in normal men, and the second in the supraphysiologic range, presumably representing a separate mechanism of action — that is, a pathway of independent androgen receptors.[URL='https://www.nejm.org/doi/full/10.1056/nejm199607043350101#']1,40[/URL] [B]Supraphysiologic doses of testosterone, with or without exercise, did not increase the occurrence of angry behavior by these carefully selected men in the controlled setting of this experiment. Our results, however, do not preclude the possibility that still higher doses of multiple steroids may provoke angry behavior in men with preexisting psychiatric or behavioral problems.[/B] Our results in no way justify the use of anabolic–androgenic steroids in sports, because, with extended use, such drugs have potentially serious adverse effects on the cardiovascular system, prostate, lipid metabolism, and insulin sensitivity. Moreover, the use of any performance-enhancing agent in sports raises serious ethical issues. Our findings do, however, raise the possibility that the short-term administration of androgens may have beneficial effects in immobilized patients, during space travel, and in patients with cancer-related cachexia, disease caused by the human immunodeficiency virus, or other chronic wasting disorders. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
TRT to Supraphysiological Levels for Body Building
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