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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trt protocal - advice needed
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<blockquote data-quote="aneuman" data-source="post: 265263" data-attributes="member: 43264"><p>Regardless what most people say anecdotally (and I value anecdotes) most studies I've read say that estradiol levels in males are tightly controlled between 20-30 pg/ml. I know some people have 40, and 60 and +80 pg/ml and feel like 20 year olds, good for them, but it seems most 25-39 year olds are actually in that range.</p><h3><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749840/" target="_blank"><span style="font-size: 12px">Age-Specific Serum Total and Free Estradiol Concentrations in Healthy Men in US Nationally Representative Samples</span></a></h3><p>You could discuss with your doctor lowering the dosage, or lowering the dosage and increasing the frequency, or maybe you do need an AI. One size does not fit all.</p><p></p><p>And yes, estradiol outside the normal range (both high and low) is associated with sexual dysfunction in males.</p><h3><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705979/" target="_blank"><span style="font-size: 12px">Estradiol is an independent risk factor for organic erectile dysfunction in eugonadal young men</span></a></h3><h3><span style="font-size: 12px"><a href="https://www.nature.com/articles/s41598-020-69712-6" target="_blank">Different levels of estradiol are correlated with sexual dysfunction in adult men</a></span></h3><p>The most optimistic study regarding higher levers of estradiol (>50pg/ml) was by Ramasamy. "<em>Most compelling is the fact that in men with <strong><u>serum testosterone <300 ng dl-</u></strong>1, sexual drive was seen to be markedly higher when estradiol levels were >5 ng dl-1</em>", but it also mentions that "<em>exposure to estradiol in the mature penis leads to increased vascular permeability with increased ED."</em></p><p></p><h3><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098/" target="_blank"><span style="font-size: 12px">The role of estradiol in male reproductive function</span></a></h3><p></p><p></p><p></p><p>I think this is a sensible conclusion. Since you've been on TRT for several years, I assume you have some labs that correlate with point in times where you were feeling good, your performance was good, etc. What were the levels of T/FT/E2 when that happened? I'd try to replicate that scenario to see if things improve.</p></blockquote><p></p>
[QUOTE="aneuman, post: 265263, member: 43264"] Regardless what most people say anecdotally (and I value anecdotes) most studies I've read say that estradiol levels in males are tightly controlled between 20-30 pg/ml. I know some people have 40, and 60 and +80 pg/ml and feel like 20 year olds, good for them, but it seems most 25-39 year olds are actually in that range. [HEADING=2][URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749840/'][SIZE=12px]Age-Specific Serum Total and Free Estradiol Concentrations in Healthy Men in US Nationally Representative Samples[/SIZE][/URL][/HEADING] You could discuss with your doctor lowering the dosage, or lowering the dosage and increasing the frequency, or maybe you do need an AI. One size does not fit all. And yes, estradiol outside the normal range (both high and low) is associated with sexual dysfunction in males. [HEADING=2][URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705979/'][SIZE=12px]Estradiol is an independent risk factor for organic erectile dysfunction in eugonadal young men[/SIZE][/URL][/HEADING] [HEADING=2][SIZE=12px][URL='https://www.nature.com/articles/s41598-020-69712-6']Different levels of estradiol are correlated with sexual dysfunction in adult men[/URL][/SIZE][/HEADING] The most optimistic study regarding higher levers of estradiol (>50pg/ml) was by Ramasamy. "[I]Most compelling is the fact that in men with [B][U]serum testosterone <300 ng dl-[/U][/B]1, sexual drive was seen to be markedly higher when estradiol levels were >5 ng dl-1[/I]", but it also mentions that "[I]exposure to estradiol in the mature penis leads to increased vascular permeability with increased ED."[/I] [HEADING=2][URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098/'][SIZE=12px]The role of estradiol in male reproductive function[/SIZE][/URL][/HEADING] I think this is a sensible conclusion. Since you've been on TRT for several years, I assume you have some labs that correlate with point in times where you were feeling good, your performance was good, etc. What were the levels of T/FT/E2 when that happened? I'd try to replicate that scenario to see if things improve. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trt protocal - advice needed
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