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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
TRT & Older Men: A Look at "The Testosterone Trials"
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<blockquote data-quote="CoastWatcher" data-source="post: 95780" data-attributes="member: 2624"><p>The Testosterone Trials are set of multi-institutional, double-blind, placebo-controlled studies aimed primarily at determining the efficacy of testosterone replacement therapy (TRT) on sexual function, physical function, and vitality.</p><p></p><ul> <li data-xf-list-type="ul">Seven hundred and ninety men over the age of 65 yr with symptoms of hypogonadism and a serum testosterone concentration of <275 ng/dl were randomized to receive either an initial dose of 5 g of 1% testosterone gel or placebo gel once a day.</li> <li data-xf-list-type="ul">Serum testosterone levels and improvement in symptoms were assessed at baseline and at 3 mo, 6 mo, 9 mo, and 12 mo.</li> <li data-xf-list-type="ul">Ninety-one percent of men maintained normalized testosterone levels throughout the duration of the study.</li> <li data-xf-list-type="ul"><strong>TRT improved sexual desire (DISF-M-II), frequency of sexual activity (Personality Diagnostic Questionnaire-4), and erectile function (International Index of Erectile Function). </strong></li> <li data-xf-list-type="ul">However, TRT did not confer any significant benefits in terms of vitality.</li> <li data-xf-list-type="ul">In the physical function trial, there was no significant difference between TRT and placebo in terms of the percentage of men with an increase of 50 m or greater in the 6-min walking distance.</li> <li data-xf-list-type="ul">However, on inclusion of all men enrolled in the three trials, TRT was associated with a significantly higher percentage of men with an increase of 50 m in the 6-min walking distance.</li> <li data-xf-list-type="ul"><strong>More men in the TRT group had an increase in prostate specific antigen 1 ng/ml, but there was no difference in the number of men diagnosed with prostate cancer 1 yr after the study period. Similarly, there was no difference in the number of men who experienced major cardiovascular events or died during the study period</strong>.</li> </ul><p></p><p>"Re: Effects of Testosterone Treatment in Older Men," <em>European Urology, </em>2016 September, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123669/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123669/</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 95780, member: 2624"] The Testosterone Trials are set of multi-institutional, double-blind, placebo-controlled studies aimed primarily at determining the efficacy of testosterone replacement therapy (TRT) on sexual function, physical function, and vitality. [LIST] [*]Seven hundred and ninety men over the age of 65 yr with symptoms of hypogonadism and a serum testosterone concentration of <275 ng/dl were randomized to receive either an initial dose of 5 g of 1% testosterone gel or placebo gel once a day. [*]Serum testosterone levels and improvement in symptoms were assessed at baseline and at 3 mo, 6 mo, 9 mo, and 12 mo. [*]Ninety-one percent of men maintained normalized testosterone levels throughout the duration of the study. [*][B]TRT improved sexual desire (DISF-M-II), frequency of sexual activity (Personality Diagnostic Questionnaire-4), and erectile function (International Index of Erectile Function). [/B] [*]However, TRT did not confer any significant benefits in terms of vitality. [*]In the physical function trial, there was no significant difference between TRT and placebo in terms of the percentage of men with an increase of 50 m or greater in the 6-min walking distance. [*]However, on inclusion of all men enrolled in the three trials, TRT was associated with a significantly higher percentage of men with an increase of 50 m in the 6-min walking distance. [*][B]More men in the TRT group had an increase in prostate specific antigen 1 ng/ml, but there was no difference in the number of men diagnosed with prostate cancer 1 yr after the study period. Similarly, there was no difference in the number of men who experienced major cardiovascular events or died during the study period[/B]. [/LIST] "Re: Effects of Testosterone Treatment in Older Men," [I]European Urology, [/I]2016 September, [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123669/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
TRT & Older Men: A Look at "The Testosterone Trials"
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