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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT + Nandrolone New Protocol
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<blockquote data-quote="Wilson7" data-source="post: 210386" data-attributes="member: 39729"><p>Nandrolone does bind with the AR (Saartok et al 1984), and weakly with SHBG. From an anabolic perspective (muscle) they are similar so it really doesn't matter, the difference as Gman mentioned is with E2 and DHT. N aromatizes to much lesser extent than T, and DHN is a weak androgen, thus the problems with ED and libido with too much N and not enough T. Topical finasteride reduces circulating DHT by 25 - 45%, about half of what you'd expect with oral FIN at 1 mg/d (Caserini 2016). HCG at 750 IU 3x/wk alone would have significant effects on T, E2 and DHT. You have alot of moving parts here and changing several variables at once (adding ND, reducing T, stopping FIN) will make it difficult to assess the effects/side-effects as what to do if you have issues. The only real way to know what is happening to circulating T, E2 and DHT is to get them checked before and after 6+ weeks to achieve steady state (ND/T), and only use LC/MS-MS or the ND will cross-react with the standard assay and you'll never know just what your true T blood conc is. Then at least you have some idea as to what is possibly causing what and adjust treatment to address only one variable at a time.</p></blockquote><p></p>
[QUOTE="Wilson7, post: 210386, member: 39729"] Nandrolone does bind with the AR (Saartok et al 1984), and weakly with SHBG. From an anabolic perspective (muscle) they are similar so it really doesn't matter, the difference as Gman mentioned is with E2 and DHT. N aromatizes to much lesser extent than T, and DHN is a weak androgen, thus the problems with ED and libido with too much N and not enough T. Topical finasteride reduces circulating DHT by 25 - 45%, about half of what you'd expect with oral FIN at 1 mg/d (Caserini 2016). HCG at 750 IU 3x/wk alone would have significant effects on T, E2 and DHT. You have alot of moving parts here and changing several variables at once (adding ND, reducing T, stopping FIN) will make it difficult to assess the effects/side-effects as what to do if you have issues. The only real way to know what is happening to circulating T, E2 and DHT is to get them checked before and after 6+ weeks to achieve steady state (ND/T), and only use LC/MS-MS or the ND will cross-react with the standard assay and you'll never know just what your true T blood conc is. Then at least you have some idea as to what is possibly causing what and adjust treatment to address only one variable at a time. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT + Nandrolone New Protocol
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