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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
TRT monotherapy. 5 week lab check due to nipple symptoms. Thoughts/Guidance please.
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<blockquote data-quote="madman" data-source="post: 273378" data-attributes="member: 13851"><p>No, you are already 5 weeks in just stick with your current protocol.</p><p></p><p>Give it a few more months before deciding on whether you need to make any adjustments.</p><p></p><p>You need to give it time for the body to adapt to its new set-point so you can gauge how you truly feel overall let alone claim whether it was a success or failure.</p><p></p><p>Anytime you tweak a protocol (dose T/injection frequency) you will need to start over as it will take another 4-6 weeks TC/TE for blood levels to stabilize.</p><p></p><p>I have posted numerous PK studies on the forum including the Nankin study you mention.</p><p></p><p>Regarding half-lives keep in mind that a majority of studies on the PK/PD of the various T-esters were done using IM (once weekly/fortnightly) injections in a small number of subjects and most of the literature is from decades ago.</p><p></p><p>Many other factors affect the rate at which testosterone is released from the oily depot at the injection site.</p><p></p><p>Sub-q vs IM, the volume of injection, injection depth, site of injection, lymphatic flow, and the concentration of BOH (benzyl alcohol) are other possible factors that can affect the absorption rates of the esterified hormone.</p><p></p><p>Keep in when using esterified testosterone whether (TC/TE/TP) that post-injection there will be an initial burst release of T and levels will start rising within the first 2 hrs.</p><p></p><p>T levels will spike up fairly quickly even when using the medium-chain esters.</p><p></p><p>Enanthate has been shown to reach Tmax 10 hrs.</p><p></p><p>When it comes to the PKs TC/TE are interchangeable.</p><p></p><p>Peak will be 8-24 hours post-injection.</p><p></p><p>Your blood work was done 48 hours post-injection so your true peak TT/FT will be higher.</p></blockquote><p></p>
[QUOTE="madman, post: 273378, member: 13851"] No, you are already 5 weeks in just stick with your current protocol. Give it a few more months before deciding on whether you need to make any adjustments. You need to give it time for the body to adapt to its new set-point so you can gauge how you truly feel overall let alone claim whether it was a success or failure. Anytime you tweak a protocol (dose T/injection frequency) you will need to start over as it will take another 4-6 weeks TC/TE for blood levels to stabilize. I have posted numerous PK studies on the forum including the Nankin study you mention. Regarding half-lives keep in mind that a majority of studies on the PK/PD of the various T-esters were done using IM (once weekly/fortnightly) injections in a small number of subjects and most of the literature is from decades ago. Many other factors affect the rate at which testosterone is released from the oily depot at the injection site. Sub-q vs IM, the volume of injection, injection depth, site of injection, lymphatic flow,[B][I] [/I][/B]and the concentration of BOH (benzyl alcohol) are other possible factors that can affect the absorption rates of the esterified hormone. Keep in when using esterified testosterone whether (TC/TE/TP) that post-injection there will be an initial burst release of T and levels will start rising within the first 2 hrs. T levels will spike up fairly quickly even when using the medium-chain esters. Enanthate has been shown to reach Tmax 10 hrs. When it comes to the PKs TC/TE are interchangeable. Peak will be 8-24 hours post-injection. Your blood work was done 48 hours post-injection so your true peak TT/FT will be higher. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
TRT monotherapy. 5 week lab check due to nipple symptoms. Thoughts/Guidance please.
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