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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
TRT monotherapy. 5 week lab check due to nipple symptoms. Thoughts/Guidance please.
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<blockquote data-quote="madman" data-source="post: 273349" data-attributes="member: 13851"><p>A decent starting dose of 120 mg T/week but not sure why you felt the need to jump in on a 3X weekly protocol.</p><p></p><p>As you would know your true trough (lowest point) on such protocol would be Monday morning just before your next injection.</p><p></p><p>You made it clear why you had blood work done on Wednesday morning which is 48 hours post-injection and as you can see you are hitting a very high TT and more importantly your FT is very high.</p><p></p><p>This was tested using what would be considered the most accurate assay (Equilibrium Dialysis).</p><p></p><p>Keep in mind that although this is not true trough even if you tested at true trough your TT/FT would still be on the high end.</p><p></p><p>You are missing critical blood markers RBCs, hemoglobin, and hematocrit which will increase when using exogenous T.</p><p></p><p>Driving up FT will drive up such blood markers within the first month after starting and will take anywhere from 6-9 months and in some cases a year to reach peak levels.</p><p></p><p>Where such blood markers sit 5 weeks in is not where they are going to end up 6-9 months from now.</p><p></p><p>Not sure where everything sat pre-trt as you never posted but there is a good chance they will be driven much higher especially when using injectable T let alone running a high FT like you are.</p><p></p><p>Something that you need to keep an eye on over the following months.</p><p></p><p>Increasing FT will drive up estradiol/DHT.</p><p></p><p>Increased nipple sensitivity can happen in some.</p><p></p><p>Much more to gynecomastia than just elevated estradiol.</p><p></p><p>If you are experiencing swelling/pain or tenderness it can be early signs of gynecomastia developing but in many cases, it will only happen to the genetically prone and is rare when using therapeutic doses of T.</p><p></p><p>As long as you do not feel a lump/rubbery mass when squeezing then I would not jump to any conclusions as of yet as your hormones are in flux during the weeks leading up until blood levels have stabilized (4-6 weeks TC/TE).</p><p></p><p>When it comes to acne let alone hair loss genetics plays a strong role and one can still have issues without having high DHT as the sensitivity of the AR (hair/skin) will play a big role.</p><p></p><p>In most cases running too high a FT will contribute to such.</p><p></p><p>Although many tend to blame estradiol when it comes to bloat/water retention keep in mind that androgens increase sodium/water.</p><p></p><p>Androgens increase the retention of electrolytes.</p><p></p><p>The use of exogenous androgens will result in the retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.</p><p></p><p>Bloating/edema can be common in some and to what degree depends on many factors.</p><p></p><p>Inhibition of corticosteroid 11β-hydroxysteroid dehydrogenase enzymes plays a role.</p><p></p><p>Most of the initial increases in weight gain on trt are water-related whether extra-cellular/intra-cellular.</p><p></p><p>Many men on trt can gain 5-15 lbs of water weight within the first month.</p><p></p><p>The majority of gains when first starting trt are due to extra-cellular water (between the muscle and skin) which shows up as bloat/puffiness and intra-cellular water (inside the muscle cell) which will make the muscle look fuller and harder due to increased glycogen stores.</p><p></p><p>Even then once the body adjusts or measures have been taken to minimize the bloat/puffiness you are always going to hold more water when using androgens as the muscle cells will retain more water (intra-cellular).</p><p></p><p>When coming off androgens, especially high doses you are always going to be pissing out the water weight (extra/intracellular).</p><p></p><p>Part of the reason why men who abuse androgens mainly the so-called wet compounds deflate when they come off is because they are holding a shit load of excess water weight which is always going to be pissed away.</p><p></p><p>If you are feeling great overall minus any significant sides then I would stick with your protocol for the time being.</p><p></p><p>Again when first starting TRT or tweaking a protocol (dose T/injection frequency) hormones will be in flux during the following weeks until blood levels have stabilized (4-6 weeks) and it is common to experience ups/downs during the transition as the body is trying to adjust.</p><p></p><p>Even once blood levels have stabilized (4-6 weeks) it will still take time (a few months) for the body to adapt to its new set-point and this is the critical period when one needs to truly gauge how they feel overall regarding relief/improvement of low-t symptoms and overall well-being.</p><p></p><p>Every protocol needs to be given a fighting chance (12 weeks) to claim whether it was truly a success or failure.</p><p></p><p>Otherwise, you will be left chasing your tail endlessly until the cows come home.</p></blockquote><p></p>
[QUOTE="madman, post: 273349, member: 13851"] A decent starting dose of 120 mg T/week but not sure why you felt the need to jump in on a 3X weekly protocol. As you would know your true trough (lowest point) on such protocol would be Monday morning just before your next injection. You made it clear why you had blood work done on Wednesday morning which is 48 hours post-injection and as you can see you are hitting a very high TT and more importantly your FT is very high. This was tested using what would be considered the most accurate assay (Equilibrium Dialysis). Keep in mind that although this is not true trough even if you tested at true trough your TT/FT would still be on the high end. You are missing critical blood markers RBCs, hemoglobin, and hematocrit which will increase when using exogenous T. Driving up FT will drive up such blood markers within the first month after starting and will take anywhere from 6-9 months and in some cases a year to reach peak levels. Where such blood markers sit 5 weeks in is not where they are going to end up 6-9 months from now. Not sure where everything sat pre-trt as you never posted but there is a good chance they will be driven much higher especially when using injectable T let alone running a high FT like you are. Something that you need to keep an eye on over the following months. Increasing FT will drive up estradiol/DHT. Increased nipple sensitivity can happen in some. Much more to gynecomastia than just elevated estradiol. If you are experiencing swelling/pain or tenderness it can be early signs of gynecomastia developing but in many cases, it will only happen to the genetically prone and is rare when using therapeutic doses of T. As long as you do not feel a lump/rubbery mass when squeezing then I would not jump to any conclusions as of yet as your hormones are in flux during the weeks leading up until blood levels have stabilized (4-6 weeks TC/TE). When it comes to acne let alone hair loss genetics plays a strong role and one can still have issues without having high DHT as the sensitivity of the AR (hair/skin) will play a big role. In most cases running too high a FT will contribute to such. Although many tend to blame estradiol when it comes to bloat/water retention keep in mind that androgens increase sodium/water. Androgens increase the retention of electrolytes. The use of exogenous androgens will result in the retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates. Bloating/edema can be common in some and to what degree depends on many factors. Inhibition of corticosteroid 11β-hydroxysteroid dehydrogenase enzymes plays a role. Most of the initial increases in weight gain on trt are water-related whether extra-cellular/intra-cellular. Many men on trt can gain 5-15 lbs of water weight within the first month. The majority of gains when first starting trt are due to extra-cellular water (between the muscle and skin) which shows up as bloat/puffiness and intra-cellular water (inside the muscle cell) which will make the muscle look fuller and harder due to increased glycogen stores. Even then once the body adjusts or measures have been taken to minimize the bloat/puffiness you are always going to hold more water when using androgens as the muscle cells will retain more water (intra-cellular). When coming off androgens, especially high doses you are always going to be pissing out the water weight (extra/intracellular). Part of the reason why men who abuse androgens mainly the so-called wet compounds deflate when they come off is because they are holding a shit load of excess water weight which is always going to be pissed away. If you are feeling great overall minus any significant sides then I would stick with your protocol for the time being. Again when first starting TRT or tweaking a protocol (dose T/injection frequency) hormones will be in flux during the following weeks until blood levels have stabilized (4-6 weeks) and it is common to experience ups/downs during the transition as the body is trying to adjust. Even once blood levels have stabilized (4-6 weeks) it will still take time (a few months) for the body to adapt to its new set-point and this is the critical period when one needs to truly gauge how they feel overall regarding relief/improvement of low-t symptoms and overall well-being. Every protocol needs to be given a fighting chance (12 weeks) to claim whether it was truly a success or failure. Otherwise, you will be left chasing your tail endlessly until the cows come home. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
TRT monotherapy. 5 week lab check due to nipple symptoms. Thoughts/Guidance please.
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