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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT & Long term Health risks
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<blockquote data-quote="Fortunate" data-source="post: 216412" data-attributes="member: 42264"><p>[USER=38590]@readalot[/USER], I came across a 2020 review of testosterone's affect on the beta adrenergic system, titled "Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes". I'm embarrassed to admit it, but I don't know how some guys are able to post external pdf's. Do you insert them as an image? You can search for this article and download a pdf if interested.</p><p></p><p>I skimmed it. Still need to read in further detail, but I think the review proposes a few mechanisms for hypertension with exogenous T, including affects on peripheral vascular tone and affects on cardiac muscle. Again, I have to read closer, but I thought of your situation. </p><p></p><p>Like you, I notice a more forceful heart beat even with really small doses of T. A separate, long term observation is that I get headaches with most forms of TRT (except Natesto). I am starting to lean towards blaming the headaches on hypertension. Even if BP elevation is transient, I suspect it could trigger a headache in someone prone to headaches (me).</p><p></p><p>Now, I am struggling with what to do about it. Calcium channel blockers and beta blockers are commonly used to prevent migraines. I have been on a calcium channel blocker for years for migraine prevention, but I wonder if a beta blocker would be more effective blunting T's affect on beta adrenergic receptors? I could go back to Natesto or attempt to stay on an injection regimen and try adding a beta blocker. But, do I really want to rely on a beta blocker just so that I can continue TRT? </p><p></p><p>Mixed feelings. TRT helps in many ways, but headaches are a problem. Natesto is the path of least resistance, but it is clearly less convenient than periodic injections. Just thinking out loud, and hoping stimulate a little more discussion on CV concerns.</p></blockquote><p></p>
[QUOTE="Fortunate, post: 216412, member: 42264"] [USER=38590]@readalot[/USER], I came across a 2020 review of testosterone's affect on the beta adrenergic system, titled "Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes". I'm embarrassed to admit it, but I don't know how some guys are able to post external pdf's. Do you insert them as an image? You can search for this article and download a pdf if interested. I skimmed it. Still need to read in further detail, but I think the review proposes a few mechanisms for hypertension with exogenous T, including affects on peripheral vascular tone and affects on cardiac muscle. Again, I have to read closer, but I thought of your situation. Like you, I notice a more forceful heart beat even with really small doses of T. A separate, long term observation is that I get headaches with most forms of TRT (except Natesto). I am starting to lean towards blaming the headaches on hypertension. Even if BP elevation is transient, I suspect it could trigger a headache in someone prone to headaches (me). Now, I am struggling with what to do about it. Calcium channel blockers and beta blockers are commonly used to prevent migraines. I have been on a calcium channel blocker for years for migraine prevention, but I wonder if a beta blocker would be more effective blunting T's affect on beta adrenergic receptors? I could go back to Natesto or attempt to stay on an injection regimen and try adding a beta blocker. But, do I really want to rely on a beta blocker just so that I can continue TRT? Mixed feelings. TRT helps in many ways, but headaches are a problem. Natesto is the path of least resistance, but it is clearly less convenient than periodic injections. Just thinking out loud, and hoping stimulate a little more discussion on CV concerns. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT & Long term Health risks
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