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Well I wouldn’t necessarily compare those swings to the diurnal swings in endogenous production from a symptomology perspective because we’re talking about two different systems… one fed by endogenous production and the other by exogenous through a mucous membrane 3x/day. Def think it’s helpful to consider from a speculation perspective though.


There are some old studies out there where they sampled T once or twice an hour for days at a time in healthy volunteers. The daily and even weekly fluctuation in T was truly eye opening. Some guys, despite hitting acceptable peaks, saw their numbers drop greater than 20%… like 50% or more for some. Despite what’s propagated out there in the ether, I don’t think we fully understand all of the nuance, intricacies, and individual variation that comprises T metabolism.


The previous Natesto studies I referenced including some of the topical and oral studies demonstrated symptomatic improvement in spite of drastic returns to baseline or low troughs. I think the one takeaway from these studies is that it’s the peaks that matter from a symptomology perspective.


Not that we should compare apples and oranges but… daily peaks and troughs are more in line with what the human body is designed and accustomed to dealing with vs the chronically high levels experienced on testosterone esters.


Just some food for thought.


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