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Message: <blockquote data-quote="Cataceous" data-source="post: 197500" data-attributes="member: 38109">These stats translate to a BMI of 29.8, at the top of the overweight category and a hair's breadth away from official obesity. This can absolutely be a contributing factor to BP issues.Obesity is a top risk factor for elevated blood pressure, though researchers remain unsure as to the exact mechanisms underlying this relationship. ... In their study paper, the investigators explain that to regulate blood flow, vessels dilate and contract as appropriate. This happens due to <a href="https://www.nature.com/subjects/calcium-signalling" target="_blank">calcium signaling</a>: Calcium ions communicate with cells, regulating vasodilation by effectively telling the vessels when to dilate. In obesity, however, calcium signaling within blood vessels appears to be impaired. This affects vasodilation and contributes to high blood pressure. Yet the mechanism underlying this impairment remains unclear. To learn more about the specific causes behind high blood pressure in obesity, the researchers investigated cellular mechanisms in human tissue samples and mice — under both normal conditions and those that induce obesity. They found that, normally, a protein called TRPV4 — which is present on the membranes of endothelial cells — allows calcium ions to enter the cells and maintain normal blood pressure. However, the researchers also found that in obesity, this protein stops “doing its job” — but only in <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1549-8719.2012.00187.x" target="_blank">myoendothelial projections</a>, which are specialized extensions of the endothelial cells.[URL unfurl="true"]https://www.medicalnewstoday.com/articles/what-is-the-mechanism-behind-high-blood-pressure-in-obesity#How-calcium-signaling-becomes-impaired[/URL]</blockquote>

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