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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
TRT Increases Risk of Kidney Stones
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<blockquote data-quote="Jinzang" data-source="post: 164277" data-attributes="member: 12925"><p>Another study finds increased risk of kidney stones. The <a href="https://link.springer.com/article/10.1007%2Fs00345-019-02726-6" target="_blank">abstract</a> says:</p><p></p><p>We conducted a population-based matched cohort study utilizing data sourced from the Military Health System Data Repository (a large military-based database that includes beneficiaries of the TRICARE program). This included men aged 40–64 years with no prior history of urolithiasis who received continuous TRT for a diagnosis of hypogonadism between 2006 and 2014. Eligible individuals were matched using both demographics and comorbidities to TRICARE enrollees who did not receive TRT. The primary outcome was 2-year absolute risk of a stone-related event, comparing men on TRT to non-TRT controls.</p><p></p><p>There were 26,586 pairs in our cohort. Four hundred and eighty-two stone-related events were observed at 2 years in the non-TRT group versus 659 in the TRT group. Log-rank comparisons showed this to be a statistically significant difference in events between the two groups (<em>p</em> < 0.0001). This difference was observed for topical (<em>p</em> < 0.0001) and injection (<em>p</em> = 0.004) therapy-type subgroups, though not for pellet (<em>p</em> = 0.27).</p></blockquote><p></p>
[QUOTE="Jinzang, post: 164277, member: 12925"] Another study finds increased risk of kidney stones. The [URL='https://link.springer.com/article/10.1007%2Fs00345-019-02726-6']abstract[/URL] says: We conducted a population-based matched cohort study utilizing data sourced from the Military Health System Data Repository (a large military-based database that includes beneficiaries of the TRICARE program). This included men aged 40–64 years with no prior history of urolithiasis who received continuous TRT for a diagnosis of hypogonadism between 2006 and 2014. Eligible individuals were matched using both demographics and comorbidities to TRICARE enrollees who did not receive TRT. The primary outcome was 2-year absolute risk of a stone-related event, comparing men on TRT to non-TRT controls. There were 26,586 pairs in our cohort. Four hundred and eighty-two stone-related events were observed at 2 years in the non-TRT group versus 659 in the TRT group. Log-rank comparisons showed this to be a statistically significant difference in events between the two groups ([I]p[/I] < 0.0001). This difference was observed for topical ([I]p[/I] < 0.0001) and injection ([I]p[/I] = 0.004) therapy-type subgroups, though not for pellet ([I]p[/I] = 0.27). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
TRT Increases Risk of Kidney Stones
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