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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
TRT Increases Marker for Heart Disease in HIV+ Men
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<blockquote data-quote="Jinzang" data-source="post: 173582" data-attributes="member: 12925"><p>If you've watched the documentary "The Widowmaker," you know the calcium artery score is a marker for risk of heart attack. A recent study, reported at an AIDS conference but not yet published, found more coronary artery calcium progression among HIV+ men on TRT than those who were not on TRT. A <a href="https://www.healio.com/cardiology/imaging/news/online/%7B2ddff344-2c32-4ae3-bd95-8b8ab9eea97b%7D/cac-progression-elevated-in-men-with-hiv-on-testosterone-therapy" target="_blank">news article on the talk</a> said:</p><p></p><p>Haberlen and colleagues analyzed 300 men with HIV aged 40 to 70 years from the CVD ancillary study of the Multicenter AIDS Cohort Study, of whom 15% were ongoing users of testosterone therapy (use at baseline and follow-up scans), 7% were new users (use at follow-up scan but not baseline scan) and 8% were former users who had stopped by the time of the follow-up scan.</p><p>At a mean follow-up of 4.5 years, compared with former users, ongoing users (adjusted RR = 1.99; <em>P</em> < .05) and new users (aRR = 2.37) had elevated risk for CAC progression, Haberlen said.</p><p>For noncalcified plaque progression, risk in new users was higher than risk in former users (aRR = 2.16; <em>P</em> < .05), but the same was not true for risk in ongoing users (aRR = 1.52; <em>P</em> > .05), she said.</p><p>“Surprisingly, the never-use group also had an elevated risk for progression compared with the former-use group, though not statistically significant,” Haberlen said.</p><p>In addition, she said, there was a relationship between baseline low serum total testosterone (< 300 ng/dL) and CAC progression (aRR = 1.97; <em>P</em> < .001), but not between low testosterone and noncalcified plaque progression (aRR = 0.97; <em>P</em> = .93).</p></blockquote><p></p>
[QUOTE="Jinzang, post: 173582, member: 12925"] If you've watched the documentary "The Widowmaker," you know the calcium artery score is a marker for risk of heart attack. A recent study, reported at an AIDS conference but not yet published, found more coronary artery calcium progression among HIV+ men on TRT than those who were not on TRT. A [URL='https://www.healio.com/cardiology/imaging/news/online/%7B2ddff344-2c32-4ae3-bd95-8b8ab9eea97b%7D/cac-progression-elevated-in-men-with-hiv-on-testosterone-therapy']news article on the talk[/URL] said: Haberlen and colleagues analyzed 300 men with HIV aged 40 to 70 years from the CVD ancillary study of the Multicenter AIDS Cohort Study, of whom 15% were ongoing users of testosterone therapy (use at baseline and follow-up scans), 7% were new users (use at follow-up scan but not baseline scan) and 8% were former users who had stopped by the time of the follow-up scan. At a mean follow-up of 4.5 years, compared with former users, ongoing users (adjusted RR = 1.99; [I]P[/I] < .05) and new users (aRR = 2.37) had elevated risk for CAC progression, Haberlen said. For noncalcified plaque progression, risk in new users was higher than risk in former users (aRR = 2.16; [I]P[/I] < .05), but the same was not true for risk in ongoing users (aRR = 1.52; [I]P[/I] > .05), she said. “Surprisingly, the never-use group also had an elevated risk for progression compared with the former-use group, though not statistically significant,” Haberlen said. In addition, she said, there was a relationship between baseline low serum total testosterone (< 300 ng/dL) and CAC progression (aRR = 1.97; [I]P[/I] < .001), but not between low testosterone and noncalcified plaque progression (aRR = 0.97; [I]P[/I] = .93). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
TRT Increases Marker for Heart Disease in HIV+ Men
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