You learn something new every day and there is so much more about E2. You should study Taeians Clarks FB group as he has a lot of out-of-the-box information spanned in 10+years of postings. Really awesome information and a mountain of knowledge with studies to back it up.
I've drank coffee for +20 years but had to let it go due to my severe gastro issues. Also it used to he hit and miss. Some days it was aight and some days it would fuck me up for all day feeling like a crackhead, wired, hot and anxious af. Considering how severe my issues is I don't fuck with it anymore. I'm using a lot of different fats and UDCA every day with 3 of my main meals and a lot more. I probably should add a tried and tested OX BILE supplement but it's expensive, as I spent a fortune already on all the stuff I'm taking and plan to take, so doing everything without it. Eating pizza and feeling great is all about lots of fats. To help digest fats we have bile which is a natural bodies antiseptic and laxative which cleans the intestines, etc and prepares for final stage digestion. Thats why when I eat fat I feel great and without fat I have massive pain, due to too much stomach acid. Add fat and it neutralises the stomach acid. And on top of that there is chronic psychological stress factor that just fucks everything up and makes a lot harder to cure and possible never cure at all, unless its mitigated. And some things in life can't be taken away just like that.
How was your medication treatment BTW?