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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT has made me worse
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<blockquote data-quote="madman" data-source="post: 207641" data-attributes="member: 13851"><p>Natesto should have a minimal impact on the shutdown of the HPG axis let alone minimize any negative impact on fertility/testicular atrophy.</p><p></p><p>Due to its short-lived peaks/long trough times when dosed (2-3X daily).</p><p></p><p>As I have stated numerous times on the forum:</p><p></p><p>The use of exogenous T whether pellets, oral, patch, buccal, transdermal (gel/cream), injectable, will result in suppression of the HPG axis.</p><p></p><p>Low dosed T patch (5 mg/daily) and Natesto would be considered the least suppressive.</p><p></p><p><em><strong>* </strong></em><strong><em>All formulations, with the exception of the short-acting ones, <u>have a target of long-term maintenance of SUSTAINED STEADY-STATE TESTOSTERONE LEVELS IN THE MID-NORMAL RANGE</u>, which leads to suppression of the endogenous activity of the HPG axis</em></strong></p><p></p><p></p><p></p><p></p><p>The main purpose of adding hCG to trt is to preserve/maintain fertility and prevent/minimize testicular atrophy.</p><p></p><p>The use of exogenous testosterone results in the suppression of ITT (intra-testicular testosterone) which is critical for sperm production.</p><p></p><p><em><strong>The main goal when using hCG is to <u>restore physiological ITT levels</u> and in order to achieve such a minimum effective dose would be needed (125-500IU) and </strong></em><strong><em>250-500IU would seem to be the sweet spot.</em></strong></p><p><strong><em></em></strong></p><p><strong><em>Anything less will have a minimal impact on increasing ITT!</em></strong></p><p></p><p>Other than one experiencing possible side effects from such doses (250-500IU) using anything <125IU will have a minimal impact on increasing ITT.</p></blockquote><p></p>
[QUOTE="madman, post: 207641, member: 13851"] Natesto should have a minimal impact on the shutdown of the HPG axis let alone minimize any negative impact on fertility/testicular atrophy. Due to its short-lived peaks/long trough times when dosed (2-3X daily). As I have stated numerous times on the forum: The use of exogenous T whether pellets, oral, patch, buccal, transdermal (gel/cream), injectable, will result in suppression of the HPG axis. Low dosed T patch (5 mg/daily) and Natesto would be considered the least suppressive. [I][B]* [/B][/I][B][I]All formulations, with the exception of the short-acting ones, [U]have a target of long-term maintenance of SUSTAINED STEADY-STATE TESTOSTERONE LEVELS IN THE MID-NORMAL RANGE[/U], which leads to suppression of the endogenous activity of the HPG axis[/I][/B] The main purpose of adding hCG to trt is to preserve/maintain fertility and prevent/minimize testicular atrophy. The use of exogenous testosterone results in the suppression of ITT (intra-testicular testosterone) which is critical for sperm production. [I][B]The main goal when using hCG is to [U]restore physiological ITT levels[/U] and in order to achieve such a minimum effective dose would be needed (125-500IU) and [/B][/I][B][I]250-500IU would seem to be the sweet spot. Anything less will have a minimal impact on increasing ITT![/I][/B] Other than one experiencing possible side effects from such doses (250-500IU) using anything <125IU will have a minimal impact on increasing ITT. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT has made me worse
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