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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT, feeling drained, high estrogen and sensitivity to anastrozole?
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<blockquote data-quote="Vettester Chris" data-source="post: 15568" data-attributes="member: 696"><p>Actually, I think Gene and Nelson are both hitting some key points, it's just a matter of piecing them together IMO. Like Gene, I go by the E2 sensitive assay, and if you're getting a 121pg reading, it's definitely over the top.</p><p></p><p>Nelson is correct just the same, as the fatigue is an after fact of earlier events ... Estrogen is needed in the right amounts for men, that we know. Like any other hormone, if you get it out of balance then every action will cause a reaction. With excessive estrogen serum levels, this could be contributing to other factors that are adding stress to the body. Again, any of these hormones in excess or that are even deficient can trigger certain reactions from the body, which is always aiming to regain homeostasis.</p><p></p><p>So, my speculation is that the high E2 is prompting the adrenals to pull more pregnenolone to produce higher levels of Cortisol. This is also fairly common with women having estrogen dominance issues during the peri and post menopausal phases, where progesterone is absent to keep the estrogen in check. This ultimately plays havoc on the adrenals, and they thyroid is also part of the casualty, as it needs cortisol to be produced in a semi-normal circadian pattern.</p><p></p><p>So it's IMO probably all the above. You have excessive high E2. The body is reacting with elevated cortisol, and depending where DHEA-S is at in relation to the circadian profile, you might be experiencing a Stage 2 Adrenal Fatigue (adapted divergence), or maybe Stage 3 at the Maladaptation Phase 1. Again, it's all speculation just based on what you described. You would have to run a complete Cortisol Saliva 4x kit w/DHEA-S saliva, plus a complete thyroid panel. Reverse T3 could also be triggered in an event like this, which would curb ATP.</p><p></p><p> On a good note, I suspect you will see much of this get corrected when you get your E2 reduced and sustained to a suitable level. However, without correction, the other issues can get worse, and then you have a whole new set of problems to manage.</p></blockquote><p></p>
[QUOTE="Vettester Chris, post: 15568, member: 696"] Actually, I think Gene and Nelson are both hitting some key points, it's just a matter of piecing them together IMO. Like Gene, I go by the E2 sensitive assay, and if you're getting a 121pg reading, it's definitely over the top. Nelson is correct just the same, as the fatigue is an after fact of earlier events ... Estrogen is needed in the right amounts for men, that we know. Like any other hormone, if you get it out of balance then every action will cause a reaction. With excessive estrogen serum levels, this could be contributing to other factors that are adding stress to the body. Again, any of these hormones in excess or that are even deficient can trigger certain reactions from the body, which is always aiming to regain homeostasis. So, my speculation is that the high E2 is prompting the adrenals to pull more pregnenolone to produce higher levels of Cortisol. This is also fairly common with women having estrogen dominance issues during the peri and post menopausal phases, where progesterone is absent to keep the estrogen in check. This ultimately plays havoc on the adrenals, and they thyroid is also part of the casualty, as it needs cortisol to be produced in a semi-normal circadian pattern. So it's IMO probably all the above. You have excessive high E2. The body is reacting with elevated cortisol, and depending where DHEA-S is at in relation to the circadian profile, you might be experiencing a Stage 2 Adrenal Fatigue (adapted divergence), or maybe Stage 3 at the Maladaptation Phase 1. Again, it's all speculation just based on what you described. You would have to run a complete Cortisol Saliva 4x kit w/DHEA-S saliva, plus a complete thyroid panel. Reverse T3 could also be triggered in an event like this, which would curb ATP. On a good note, I suspect you will see much of this get corrected when you get your E2 reduced and sustained to a suitable level. However, without correction, the other issues can get worse, and then you have a whole new set of problems to manage. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT, feeling drained, high estrogen and sensitivity to anastrozole?
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