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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?
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<blockquote data-quote="Cataceous" data-source="post: 203355" data-attributes="member: 38109"><p>Near the end Dr. Gordon does seem to say that levels of 5ar are lower when testosterone is high, and they're doing a study on how to restore them. It would be interesting to know the mechanism. Otherwise it's easy to imagine a situation with competitive inhibition, where there's so much testosterone relative to progesterone that less progesterone can be converted to allopregnanolone via 5a-dihydroprogesterone.</p><p></p><p>It's gratifying to see that Dr. Gordon shares some of the ideas that have been promoted here: the disruption of the hormonal milieu caused by TRT—he mentions 35 hormones being affected; in replacement, aiming for median hormone levels rather than significantly higher—though my version uses median levels for healthy young men; avoiding the use of higher and higher levels of testosterone to solve problems—he said it's like trying to pump up only one flat tire on your car when all of them are flat—it means there's "no balance".</p></blockquote><p></p>
[QUOTE="Cataceous, post: 203355, member: 38109"] Near the end Dr. Gordon does seem to say that levels of 5ar are lower when testosterone is high, and they're doing a study on how to restore them. It would be interesting to know the mechanism. Otherwise it's easy to imagine a situation with competitive inhibition, where there's so much testosterone relative to progesterone that less progesterone can be converted to allopregnanolone via 5a-dihydroprogesterone. It's gratifying to see that Dr. Gordon shares some of the ideas that have been promoted here: the disruption of the hormonal milieu caused by TRT—he mentions 35 hormones being affected; in replacement, aiming for median hormone levels rather than significantly higher—though my version uses median levels for healthy young men; avoiding the use of higher and higher levels of testosterone to solve problems—he said it's like trying to pump up only one flat tire on your car when all of them are flat—it means there's "no balance". [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?
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