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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?
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<blockquote data-quote="Fortunate" data-source="post: 203303" data-attributes="member: 42264"><p>[USER=3]@Nelson Vergel[/USER], that was a great summary of steroidogenesis and why we should all consider hCG. I personally have used it for years, while jumping around on various forms of TRT. I have (non-scientifically) started to suspect hCG may be contributing to developing headaches, so I have gone off for periods of time. Anecdotally, I do think headache frequency has dropped while off it.</p><p></p><p>Another issue I have noticed is what is described above as the six-month problems. In my case, after starting Xyosted, I felt really good for several months and then started to feel like crap. I got labs and T levels were a bit high (not crazy) and E2 was higher than usual. I blamed the crappy feeling on E2, started a tiny dose of anastrazole and struggled to find the "zone" again. Since then, have been trying different protocols.</p><p></p><p>I would love to have a "culprit" for both my headaches and the six-month crash and it would be great if I could just blame hCG. Maybe TRT alone without hCG is my answer. I may be exploring that, but based on what we know (as demonstrated by your excellent summary), hCG actually does more than just stimulate Leydig cells.</p><p></p><p>I watched portions of Dr. Gordon's presentation, but still need to watch the whole thing. It seemed to me that he is a proponent of supplementing with some of the upstream end-products (pregnenelone). It seems that the "natural" way to get upstream hormone production would be to use an LH analogue (hCG). But, if anxiety (and in my case, headaches) are an issue you are trying to resolve, and if one concludes hCG somehow contributes to these issue, I wonder if simply supplementing with pregnenolone and/or DHEA will get us in the same place (provide us with needed upstream hormones)?</p><p></p><p>Most of this is just my thinking out loud, but if I had a direct question it would be: for those who suspect they don't tolerate hCG, would supplement with pregnenlone and/or DHEA suffice as a way to maintain healthy levels of those hormones?</p><p></p><p>I have used DHEA in the past, but I noticed that it makes me really sleepy, so I tend to use it before bed. I have never used pregnenolone and might be interested in trying it to see how it affects mood.</p><p></p><p>Would love to anyone's thoughts on my ramble <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink ;)" loading="lazy" data-shortname=";)" /></p></blockquote><p></p>
[QUOTE="Fortunate, post: 203303, member: 42264"] [USER=3]@Nelson Vergel[/USER], that was a great summary of steroidogenesis and why we should all consider hCG. I personally have used it for years, while jumping around on various forms of TRT. I have (non-scientifically) started to suspect hCG may be contributing to developing headaches, so I have gone off for periods of time. Anecdotally, I do think headache frequency has dropped while off it. Another issue I have noticed is what is described above as the six-month problems. In my case, after starting Xyosted, I felt really good for several months and then started to feel like crap. I got labs and T levels were a bit high (not crazy) and E2 was higher than usual. I blamed the crappy feeling on E2, started a tiny dose of anastrazole and struggled to find the "zone" again. Since then, have been trying different protocols. I would love to have a "culprit" for both my headaches and the six-month crash and it would be great if I could just blame hCG. Maybe TRT alone without hCG is my answer. I may be exploring that, but based on what we know (as demonstrated by your excellent summary), hCG actually does more than just stimulate Leydig cells. I watched portions of Dr. Gordon's presentation, but still need to watch the whole thing. It seemed to me that he is a proponent of supplementing with some of the upstream end-products (pregnenelone). It seems that the "natural" way to get upstream hormone production would be to use an LH analogue (hCG). But, if anxiety (and in my case, headaches) are an issue you are trying to resolve, and if one concludes hCG somehow contributes to these issue, I wonder if simply supplementing with pregnenolone and/or DHEA will get us in the same place (provide us with needed upstream hormones)? Most of this is just my thinking out loud, but if I had a direct question it would be: for those who suspect they don't tolerate hCG, would supplement with pregnenlone and/or DHEA suffice as a way to maintain healthy levels of those hormones? I have used DHEA in the past, but I noticed that it makes me really sleepy, so I tend to use it before bed. I have never used pregnenolone and might be interested in trying it to see how it affects mood. Would love to anyone's thoughts on my ramble ;) [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?
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