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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?
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<blockquote data-quote="Nelson Vergel" data-source="post: 203282" data-attributes="member: 3"><p>I am sorry that it took me a long time to jump in. I have been busy with work.</p><p></p><p>I think there is something to this.</p><p></p><p>Some guys may be more susceptible to the decrease in neuro-steroids (pregnenolone, progesterone) that is caused by TRT due to its shut down effect on LH.</p><p></p><p>Reference: <a href="https://www.excelmale.com/forum/threads/anabolic-steroids-and-trt-decrease-shbg-dhea-pregnenolone-and-progesterone-in-men.3990/" target="_blank">Anabolic steroids and TRT decrease SHBG, DHEA, pregnenolone and progesterone in men.</a></p><p></p><p>[ATTACH=full]15115[/ATTACH]</p><p>I explain how LH may be involved in the synthesis of pregnenolone and progesterone from cholesterol in this video (and the effect of hCG as a LH analog). TRT shuts down LH, and thus it decreases pregenenolone and its downstream hormones. The adrenals can still make some pregnenolone, but in men with some adrenal insufficiency, that may be extremely limited and not enough to compensate for the effect of shutting down LH.</p><p></p><p>[MEDIA=youtube]ELzmOQG6Y_Y[/MEDIA]</p><p></p><p></p><p>As we know, progesterone is a "calming" hormone.</p><p></p><p>[ATTACH=full]15117[/ATTACH]</p><p></p><p>We need pregnenolone to make progesterone and we need progesterone to make allopregnanolone, a hormone that has been tied to mood. Any effect on 5 alpha reductase (enzyme also responsible for converting testosterone to DHT), can affect allopregnanolone. Allopregnanolone has been linked to mood disorders.</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/allopregnanolone-in-mood-disorders.23480/[/URL]</p><p></p><p></p><p>I felt really tired and had low mood when taking a DHT analog like oxandrolone (with TRT) that may affect the action of 5 alpha reductase. This enzyme is not only key to converting testosterone to DHT but also progesterone to allopregnanolone.</p><p></p><p>Some men on 5 alpha reductase inhibitors like finasteride have experienced more depression (due to the lack or low allopregnanolone?). <a href="https://www.healio.com/news/primary-care/20170321/increased-selfharm-depression-risks-associated-with-5alphareductase-inhibitors" target="_blank">Increased self-harm, depression risks associated with 5-alpha-reductase inhibitors</a></p><p></p><p>Why do some men feel great on TRT (and/or hCG) and others don't? That is the question that I have seen no data on. My hypothesis is that there are genetic or adrenal factors that may make some men more susceptible to lowering upstream neuro-steroids. Some of us supplement pregnenolone and/or progesterone to compensate, but I have honestly not seen enough evidence to see if this improves mood and quality of life. I started pregnenolone 100 mg every night 3 weeks ago and I think I am sleeping better and may have some improvements in the low mood I have had lately. I will test my preg, prog, and other levels next week using this panel:</p><p></p><p>[URL unfurl="true"]https://www.discountedlabs.com/hormone-panel-for-men-on-trt-comprehensive[/URL]</p><p></p><p>I think we have no good data on testosterone-induced anxiety. Some studies (not done in men on TRT) have hinted to the fact that high testosterone can increase the odds of anxiety. But most men I know feel better, not worse, on TRT.</p><p></p><p>[URL unfurl="true"]https://www.psychiatryadvisor.com/home/topics/anxiety/high-levels-of-androgens-in-men-associated-with-increased-risk-for-anxiety-disorders/[/URL]</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 203282, member: 3"] I am sorry that it took me a long time to jump in. I have been busy with work. I think there is something to this. Some guys may be more susceptible to the decrease in neuro-steroids (pregnenolone, progesterone) that is caused by TRT due to its shut down effect on LH. Reference: [URL='https://www.excelmale.com/forum/threads/anabolic-steroids-and-trt-decrease-shbg-dhea-pregnenolone-and-progesterone-in-men.3990/']Anabolic steroids and TRT decrease SHBG, DHEA, pregnenolone and progesterone in men.[/URL] [ATTACH type="full" alt="steroidogenesis-sexhormone upstream.png"]15115[/ATTACH] I explain how LH may be involved in the synthesis of pregnenolone and progesterone from cholesterol in this video (and the effect of hCG as a LH analog). TRT shuts down LH, and thus it decreases pregenenolone and its downstream hormones. The adrenals can still make some pregnenolone, but in men with some adrenal insufficiency, that may be extremely limited and not enough to compensate for the effect of shutting down LH. [MEDIA=youtube]ELzmOQG6Y_Y[/MEDIA] As we know, progesterone is a "calming" hormone. [ATTACH type="full"]15117[/ATTACH] We need pregnenolone to make progesterone and we need progesterone to make allopregnanolone, a hormone that has been tied to mood. Any effect on 5 alpha reductase (enzyme also responsible for converting testosterone to DHT), can affect allopregnanolone. Allopregnanolone has been linked to mood disorders. [URL unfurl="true"]https://www.excelmale.com/forum/threads/allopregnanolone-in-mood-disorders.23480/[/URL] I felt really tired and had low mood when taking a DHT analog like oxandrolone (with TRT) that may affect the action of 5 alpha reductase. This enzyme is not only key to converting testosterone to DHT but also progesterone to allopregnanolone. Some men on 5 alpha reductase inhibitors like finasteride have experienced more depression (due to the lack or low allopregnanolone?). [URL='https://www.healio.com/news/primary-care/20170321/increased-selfharm-depression-risks-associated-with-5alphareductase-inhibitors']Increased self-harm, depression risks associated with 5-alpha-reductase inhibitors[/URL] Why do some men feel great on TRT (and/or hCG) and others don't? That is the question that I have seen no data on. My hypothesis is that there are genetic or adrenal factors that may make some men more susceptible to lowering upstream neuro-steroids. Some of us supplement pregnenolone and/or progesterone to compensate, but I have honestly not seen enough evidence to see if this improves mood and quality of life. I started pregnenolone 100 mg every night 3 weeks ago and I think I am sleeping better and may have some improvements in the low mood I have had lately. I will test my preg, prog, and other levels next week using this panel: [URL unfurl="true"]https://www.discountedlabs.com/hormone-panel-for-men-on-trt-comprehensive[/URL] I think we have no good data on testosterone-induced anxiety. Some studies (not done in men on TRT) have hinted to the fact that high testosterone can increase the odds of anxiety. But most men I know feel better, not worse, on TRT. [URL unfurl="true"]https://www.psychiatryadvisor.com/home/topics/anxiety/high-levels-of-androgens-in-men-associated-with-increased-risk-for-anxiety-disorders/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?
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