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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
TRT and saturation of dopamine receptors
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<blockquote data-quote="johndoesmith" data-source="post: 54247" data-attributes="member: 13404"><p>I think this post is a bit short sighted. It assumes that testosterone has a large or even the largest impact on dopamine levels as opposed to other hormones or systems that regulate dopamine production and release.</p><p></p><p>It also seems as if he is advocating for once a month injections, but he said it gives him pause so I don't think so. </p><p></p><p>Then it mentions maintaining low normal levels of testosterone while on TRT. I would say that from reading the members who post on here, that guys who have 400-500 troughs complain the most about not feeling that great. I don't have evidence to back this up, but it's a bit counter intuitive. Who wants to maintain trough levels at 400-500 when taking all of the effort, money, and risk of TRT?</p><p></p><p>I personally don't think testosterone can be compared to a dopamine agonist, releaser, or reuptake inhibitor such as cocaine or amphetamines, where significant down regulation of dopamine receptors occur. </p><p></p><p>Another thing is, it seems to be this post is advocating treating something that is only a problem in theory, it's one thing if guys who are maintaining high normal troughs are complaining of issues, and you try this, but I don't think that is what <span style="color: #3E3E3E">Dr. Marianco is suggesting.</span></p><p><span style="color: #3E3E3E"></span></p><p><span style="color: #3E3E3E">I do recall a post on here by Dr saya where he was asked if cycling TRT would allow a guy to reexperience the honeymoon period, and Dr saya explained that you could, but only at the trade off of experiencing the low testosterone blues for months. I will look for it. If anyone else finds it please post it here.</span></p></blockquote><p></p>
[QUOTE="johndoesmith, post: 54247, member: 13404"] I think this post is a bit short sighted. It assumes that testosterone has a large or even the largest impact on dopamine levels as opposed to other hormones or systems that regulate dopamine production and release. It also seems as if he is advocating for once a month injections, but he said it gives him pause so I don't think so. Then it mentions maintaining low normal levels of testosterone while on TRT. I would say that from reading the members who post on here, that guys who have 400-500 troughs complain the most about not feeling that great. I don't have evidence to back this up, but it's a bit counter intuitive. Who wants to maintain trough levels at 400-500 when taking all of the effort, money, and risk of TRT? I personally don't think testosterone can be compared to a dopamine agonist, releaser, or reuptake inhibitor such as cocaine or amphetamines, where significant down regulation of dopamine receptors occur. Another thing is, it seems to be this post is advocating treating something that is only a problem in theory, it's one thing if guys who are maintaining high normal troughs are complaining of issues, and you try this, but I don't think that is what [COLOR=#3E3E3E]Dr. Marianco is suggesting. I do recall a post on here by Dr saya where he was asked if cycling TRT would allow a guy to reexperience the honeymoon period, and Dr saya explained that you could, but only at the trade off of experiencing the low testosterone blues for months. I will look for it. If anyone else finds it please post it here.[/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
TRT and saturation of dopamine receptors
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