ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT and HCG levels
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 183049" data-attributes="member: 38109"><p>As I said, it's a pretty rough calculation. What else goes into it? The time to reach peak serum testosterone is neglected. I think this is justified, but there's some opposing data suggesting it's longer than the few hours I assume. The fall in serum testosterone is modeled as an exponential decay: Serum_T = Peak_T * exp(-ln(2) * time / half_life)</p><p></p><p>For E7D dosing the calculated reduction from peak to trough is 0.38. For simplicity I just call it one third, putting the peak value at around three times the trough. For E3.5D dosing the reduction is 0.71, which for simplicity I call two thirds, putting the peak value at around 1.5 times the trough.</p><p></p><p>Another simplification is used to estimate average serum testosterone. The exponential decay function is fairly linear in this range, so the average is simply assumed to be peak plus trough divided by two.</p><p></p><p>So for your trough of 500 ng/dL at seven days we multiply by three to get a peak of 1500, then take the average of peak and trough to get 1000. Then we work things in reverse to see where the 3.5-day trough is when average testosterone is 1000.</p><p></p><p>The apparent half-lives of testosterone esters aren't set in stone, and yes, there probably is some dependence on dose size, with smaller doses having shorter half-lives. Nonetheless, the best research I've seen, along with a fair bit of data provided by forum members, seem to show five days as a good half-life figure for testosterone cypionate. Contradictions of this would tend to be higher, e.g. 7-10 days, not lower.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 183049, member: 38109"] As I said, it's a pretty rough calculation. What else goes into it? The time to reach peak serum testosterone is neglected. I think this is justified, but there's some opposing data suggesting it's longer than the few hours I assume. The fall in serum testosterone is modeled as an exponential decay: Serum_T = Peak_T * exp(-ln(2) * time / half_life) For E7D dosing the calculated reduction from peak to trough is 0.38. For simplicity I just call it one third, putting the peak value at around three times the trough. For E3.5D dosing the reduction is 0.71, which for simplicity I call two thirds, putting the peak value at around 1.5 times the trough. Another simplification is used to estimate average serum testosterone. The exponential decay function is fairly linear in this range, so the average is simply assumed to be peak plus trough divided by two. So for your trough of 500 ng/dL at seven days we multiply by three to get a peak of 1500, then take the average of peak and trough to get 1000. Then we work things in reverse to see where the 3.5-day trough is when average testosterone is 1000. The apparent half-lives of testosterone esters aren't set in stone, and yes, there probably is some dependence on dose size, with smaller doses having shorter half-lives. Nonetheless, the best research I've seen, along with a fair bit of data provided by forum members, seem to show five days as a good half-life figure for testosterone cypionate. Contradictions of this would tend to be higher, e.g. 7-10 days, not lower. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT and HCG levels
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top