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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT and Fertility
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<blockquote data-quote="madman" data-source="post: 185749" data-attributes="member: 13851"><p>The hpta will be shutdown when using exogenous testosterone and the only option to maintain fertility would be through the addition of hCG which will maintain ITT (intra-testicular testosterone).</p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/new-frontiers-in-fertility-preservation-a-hypothesis-on-fertility-optimization-in-men-with-hypergonadotrophic-hypogonadism.20851/[/URL]</p><p></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>*</strong></span><span style="color: rgb(184, 49, 47)">High intratesticular testosterone (ITT) levels maintain the spermatogenic process and prevent germ cell death. Low ITT levels result in an impaired blood-testis barrier permitting immune cells to enter the seminiferous tubules and attack autoantigenic germ cells. Low intratesticular testosterone levels also block the conversion of round spermatids to elongating spermatogonia and prevent spermiation, leading to phagocytosis of spermatids </span></p><p><span style="color: rgb(184, 49, 47)">by Sertoli cells. </span></p><p></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>*</strong></span><span style="color: rgb(184, 49, 47)"><u><strong>It is well established that exogenous testosterone therapy causes azoospermia in the majority of men</strong></u>. </span><span style="color: rgb(0, 0, 0)"><strong><u>Exogenous testosterone’s contraceptive effect occurs through its suppression of the HPG axis, preventing LH and FSH release and their respective gonadal functions</u>.</strong> </span><span style="color: rgb(184, 49, 47)">Studies examining the reproductive outcomes and rates of azoospermia development of various testosterone treatment modalities show less detrimental effects with testosterone patches [24% rate of azoospermia] compared to intramuscular injections of testosterone enanthate, which result in up to a 98% rate of combined azoospermia and oligozoospermia (≤3 million/cc) after 1 year of therapy. </span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"><strong><u>Novel methods of treating hypogonadal symptoms and keeping men fertile include the use of nasal testosterone and resetting the HPG axis with TRT and controlled administration of HCG. </u></strong>While preliminary results suggest that these methods may increase success for fertility treatments, more extensive research is needed to demonstrate the efficacy and safety of these therapies. The most recent evidence provides hope for the future of male fertility in patients that require TRT. </span></p><p></p><p></p><p></p><p></p><p>Alternatives to trt would be Natesto or clomid/enclomiphene.</p><p></p><p><span style="color: rgb(0, 0, 0)">You could look into Natesto as you have already tried Clomid/Enclomiphene which you did not like...</span></p></blockquote><p></p>
[QUOTE="madman, post: 185749, member: 13851"] The hpta will be shutdown when using exogenous testosterone and the only option to maintain fertility would be through the addition of hCG which will maintain ITT (intra-testicular testosterone). [URL unfurl="true"]https://www.excelmale.com/forum/threads/new-frontiers-in-fertility-preservation-a-hypothesis-on-fertility-optimization-in-men-with-hypergonadotrophic-hypogonadism.20851/[/URL] [COLOR=rgb(0, 0, 0)][B]*[/B][/COLOR][COLOR=rgb(184, 49, 47)]High intratesticular testosterone (ITT) levels maintain the spermatogenic process and prevent germ cell death. Low ITT levels result in an impaired blood-testis barrier permitting immune cells to enter the seminiferous tubules and attack autoantigenic germ cells. Low intratesticular testosterone levels also block the conversion of round spermatids to elongating spermatogonia and prevent spermiation, leading to phagocytosis of spermatids by Sertoli cells. [/COLOR] [COLOR=rgb(0, 0, 0)][B]*[/B][/COLOR][COLOR=rgb(184, 49, 47)][U][B]It is well established that exogenous testosterone therapy causes azoospermia in the majority of men[/B][/U]. [/COLOR][COLOR=rgb(0, 0, 0)][B][U]Exogenous testosterone’s contraceptive effect occurs through its suppression of the HPG axis, preventing LH and FSH release and their respective gonadal functions[/U].[/B] [/COLOR][COLOR=rgb(184, 49, 47)]Studies examining the reproductive outcomes and rates of azoospermia development of various testosterone treatment modalities show less detrimental effects with testosterone patches [24% rate of azoospermia] compared to intramuscular injections of testosterone enanthate, which result in up to a 98% rate of combined azoospermia and oligozoospermia (≤3 million/cc) after 1 year of therapy. [B][U]Novel methods of treating hypogonadal symptoms and keeping men fertile include the use of nasal testosterone and resetting the HPG axis with TRT and controlled administration of HCG. [/U][/B]While preliminary results suggest that these methods may increase success for fertility treatments, more extensive research is needed to demonstrate the efficacy and safety of these therapies. The most recent evidence provides hope for the future of male fertility in patients that require TRT. [/COLOR] Alternatives to trt would be Natesto or clomid/enclomiphene. [COLOR=rgb(0, 0, 0)]You could look into Natesto as you have already tried Clomid/Enclomiphene which you did not like...[/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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