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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
TRT and Cardiovascular Disease: A New Report Supports the Use of Testosterone
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<blockquote data-quote="CoastWatcher" data-source="post: 81986" data-attributes="member: 2624"><p>It's a question that many men anxiously ask their doctor: "Will a TRT protocol cause heart disease?" A great deal of mis-information has provoked articles in the popular press that raise all sorts of concerns, despite that fact that a number of studies have shown that testosterone is safe and not a factor in cardiac-related events. A new report appeared in the <em>Asian Journal of Urology</em>, "Testosterone Treatment and Cardiovascular Events in Prescription Database Studies," September 2017, concluded "<strong>T treatment was not associated with increased risks for thrombosis, MI, stroke, composite CV events, or mortality."</strong></p><p><strong></strong></p><p><strong></strong>The paper reviewed retrospective/observational studies using prescription databases to the examine the association of testosterone treatment with the above-referenced morbidities. A literature search yielded eligible studies that were either retrospective cohort or case-control studies analyzing prescription or insurance claim databases. Fourteen studies were examined. </p><p></p><p><strong>Summary of Results by Specific Outcomes</strong></p><p><strong></strong></p><ul> <li data-xf-list-type="ul"><strong>MI (Myocardial Infarction): </strong></li> </ul><p>Several large MI-focused studies "found no increased risk for MI with T treatment. The largest of these was a well-designed study that included approximately 65,000 T-treated men an reported a 24% decreased risk for MI with T treatment."</p><p></p><ul> <li data-xf-list-type="ul"><strong>Stroke</strong></li> </ul><p></p><p>In three studies of stroke, "T treatment was not associated with an increased risk of stroke." The same study referenced in the MI results section (above) reported a 36% decreased risk for stroke with T treatment.</p><p></p><p></p><ul> <li data-xf-list-type="ul"><strong>Composite CV Outcomes </strong></li> </ul><p></p><p>Three studies reported conflicting results on the association of T treatment and composite CV outcomes. However, at least one of those studies was poorly designed.</p><p></p><p></p><ul> <li data-xf-list-type="ul"><strong>Thrombosis</strong></li> </ul><p></p><p>Four studies indicated that treatment with testosterone was not associated with an elevated risk for thrombosis. One study indicated an increased risk of such an event.</p><p></p><p></p><ul> <li data-xf-list-type="ul"><strong>Mortality</strong></li> </ul><p></p><p>No study found an overall increased mortality risk for men being treated with testosterone. The decreased mortality risk (all-cause mortality) ranged from 22%-66%. </p><p></p><p> <strong>Conclusion</strong></p><p><strong></strong></p><p><strong></strong>The studies examined over 215,000 men being treated with testosterone. Most, by a substantial majority, showed that such treatment was not associated with cardiovascular disease/mortality. However, the author points out that - given the nature and limitations of retrospective, observational data - discussion and debate will likely continue until a large, prospective randomized, double-blind, placebo-controlled study is undertaken. </p><p></p><p>The abstract for this article is linked below. For a short time the full-text will also be available.</p><p></p><p><a href="http://www.ajandrology.com/preprintarticle.asp?id=212903;type=0" target="_blank">http://www.ajandrology.com/preprintarticle.asp?id=212903;type=0</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 81986, member: 2624"] It's a question that many men anxiously ask their doctor: "Will a TRT protocol cause heart disease?" A great deal of mis-information has provoked articles in the popular press that raise all sorts of concerns, despite that fact that a number of studies have shown that testosterone is safe and not a factor in cardiac-related events. A new report appeared in the [I]Asian Journal of Urology[/I], "Testosterone Treatment and Cardiovascular Events in Prescription Database Studies," September 2017, concluded "[B]T treatment was not associated with increased risks for thrombosis, MI, stroke, composite CV events, or mortality." [/B]The paper reviewed retrospective/observational studies using prescription databases to the examine the association of testosterone treatment with the above-referenced morbidities. A literature search yielded eligible studies that were either retrospective cohort or case-control studies analyzing prescription or insurance claim databases. Fourteen studies were examined. [B]Summary of Results by Specific Outcomes [/B] [LIST] [*][B]MI (Myocardial Infarction): [/B] [/LIST] Several large MI-focused studies "found no increased risk for MI with T treatment. The largest of these was a well-designed study that included approximately 65,000 T-treated men an reported a 24% decreased risk for MI with T treatment." [LIST] [*][B]Stroke[/B] [/LIST] In three studies of stroke, "T treatment was not associated with an increased risk of stroke." The same study referenced in the MI results section (above) reported a 36% decreased risk for stroke with T treatment. [LIST] [*][B]Composite CV Outcomes [/B] [/LIST] Three studies reported conflicting results on the association of T treatment and composite CV outcomes. However, at least one of those studies was poorly designed. [LIST] [*][B]Thrombosis[/B] [/LIST] Four studies indicated that treatment with testosterone was not associated with an elevated risk for thrombosis. One study indicated an increased risk of such an event. [LIST] [*][B]Mortality[/B] [/LIST] No study found an overall increased mortality risk for men being treated with testosterone. The decreased mortality risk (all-cause mortality) ranged from 22%-66%. [B]Conclusion [/B]The studies examined over 215,000 men being treated with testosterone. Most, by a substantial majority, showed that such treatment was not associated with cardiovascular disease/mortality. However, the author points out that - given the nature and limitations of retrospective, observational data - discussion and debate will likely continue until a large, prospective randomized, double-blind, placebo-controlled study is undertaken. The abstract for this article is linked below. For a short time the full-text will also be available. [URL]http://www.ajandrology.com/preprintarticle.asp?id=212903;type=0[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
TRT and Cardiovascular Disease: A New Report Supports the Use of Testosterone
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