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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
TRT after treatment for prostate cancer
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<blockquote data-quote="madman" data-source="post: 204921" data-attributes="member: 13851"><p>Sorry to hear you have been going through this.</p><p></p><p>Your T levels are horribly low.....21 ng/dL and hard to believe anyone could deal with such.</p><p></p><p>Having such levels is far from healthy let alone would negatively impact your overall health in the long run.</p><p></p><p>Here is one of the more recent papers regarding PCa/TTh.</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-therapy-after-prostate-cancer-treatment-a-review-of-literature.23336/#post-200234[/URL]</p><p></p><p></p><p><strong>Treatment of Testosterone Deficiency With TTh After External Beam Radiation Therapy </strong></p><p></p><p><em><strong>EBRT, which involves the delivery of radiation externally to target tumor cells, is the most used form of radiation in locally advanced prostate cancer. It has been demonstrated to be ineffective when used alone, so the combination with hormonal therapy has traditionally been observed.39</strong> In a study by Morales et al, 5 men with symptoms of testosterone deficiency after EBRT were treated with TTh.40 2 patients had Gleason scores of 6, one had a score of 7, and 2 had scores of 8. These patients were followed up for an average of 14.5 months and included an assessment of prostate health via DRE and PSA, TTh response, hematological evaluation, and lipid profiles. Side effects encountered in this study included headaches in one patient, who subsequently ceased treatment as a result. </em><strong><em>The results of the study showed no recurrence of prostate cancer, defined as PSA levels >1.5 ng/mL, during follow-up. All patients reported improvements in hypogonadal symptoms. 4 reported decreased hot flushes, decreased fatigue, and increased libido, whereas 2 subjects reported improved erectile dysfunction.40 The authors concluded that men with testosterone deficiency syndrome after EBRT for localized prostate cancer are candidates for TTh.</em></strong><em> A retrospective study conducted by Davila et al assessed 6 men who received TTh after EBRT.19 The mean Gleason's score was 5. Testosterone and PSA values were measured both before and after treatment.</em><strong> <em>The team found that TTh (administered by injection or transdermal gel) was effective in improving hypogonadal symptoms. 89% of the subjects elected to remain on TTh indefinitely. In addition, no significant differences were found between pre-and post-PSA levels.</em></strong></p><p><strong><em></em></strong></p><p><strong><em><u>Many studies published in the last 15 years demonstrate the safety of TTh in patients previously treated with localized definitive therapy for prostate cancer, and it is important to acknowledge that close follow-up may be important and is recommended by both the EAU and the AUA</u>.</em></strong><em> Both guidelines suggest that follow-up be offered at 3, 6, and 12 months after the onset of treatment and every 6-12 months thereafter.39,41 In addition, both organizations recommend monitoring hematocrit and performing DREs, with PSA monitoring also recommended by the EAU.41</em></p><p></p><p></p><p></p><p></p><p><strong>CONCLUSION</strong></p><p><strong></strong></p><p><strong><em>Available evidence suggests that administration of TTh for the treatment of testosterone deficiency appears to be safe in patients previously treated with definitive local therapy for prostate cancer. This review validates this finding in patients treated either with surgical therapy or single or multimodal radiotherapy. <u>Owing to the limited availability of randomized controlled trials, clinicians should remain vigilant when selecting appropriate patients to administer TTh in secondary hypogonadal men with a history of prostate cancer</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 204921, member: 13851"] Sorry to hear you have been going through this. Your T levels are horribly low.....21 ng/dL and hard to believe anyone could deal with such. Having such levels is far from healthy let alone would negatively impact your overall health in the long run. Here is one of the more recent papers regarding PCa/TTh. [URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-therapy-after-prostate-cancer-treatment-a-review-of-literature.23336/#post-200234[/URL] [B]Treatment of Testosterone Deficiency With TTh After External Beam Radiation Therapy [/B] [I][B]EBRT, which involves the delivery of radiation externally to target tumor cells, is the most used form of radiation in locally advanced prostate cancer. It has been demonstrated to be ineffective when used alone, so the combination with hormonal therapy has traditionally been observed.39[/B] In a study by Morales et al, 5 men with symptoms of testosterone deficiency after EBRT were treated with TTh.40 2 patients had Gleason scores of 6, one had a score of 7, and 2 had scores of 8. These patients were followed up for an average of 14.5 months and included an assessment of prostate health via DRE and PSA, TTh response, hematological evaluation, and lipid profiles. Side effects encountered in this study included headaches in one patient, who subsequently ceased treatment as a result. [/I][B][I]The results of the study showed no recurrence of prostate cancer, defined as PSA levels >1.5 ng/mL, during follow-up. All patients reported improvements in hypogonadal symptoms. 4 reported decreased hot flushes, decreased fatigue, and increased libido, whereas 2 subjects reported improved erectile dysfunction.40 The authors concluded that men with testosterone deficiency syndrome after EBRT for localized prostate cancer are candidates for TTh.[/I][/B][I] A retrospective study conducted by Davila et al assessed 6 men who received TTh after EBRT.19 The mean Gleason's score was 5. Testosterone and PSA values were measured both before and after treatment.[/I][B] [I]The team found that TTh (administered by injection or transdermal gel) was effective in improving hypogonadal symptoms. 89% of the subjects elected to remain on TTh indefinitely. In addition, no significant differences were found between pre-and post-PSA levels. [U]Many studies published in the last 15 years demonstrate the safety of TTh in patients previously treated with localized definitive therapy for prostate cancer, and it is important to acknowledge that close follow-up may be important and is recommended by both the EAU and the AUA[/U].[/I][/B][I] Both guidelines suggest that follow-up be offered at 3, 6, and 12 months after the onset of treatment and every 6-12 months thereafter.39,41 In addition, both organizations recommend monitoring hematocrit and performing DREs, with PSA monitoring also recommended by the EAU.41[/I] [B]CONCLUSION [I]Available evidence suggests that administration of TTh for the treatment of testosterone deficiency appears to be safe in patients previously treated with definitive local therapy for prostate cancer. This review validates this finding in patients treated either with surgical therapy or single or multimodal radiotherapy. [U]Owing to the limited availability of randomized controlled trials, clinicians should remain vigilant when selecting appropriate patients to administer TTh in secondary hypogonadal men with a history of prostate cancer[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
TRT after treatment for prostate cancer
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