Hi ERO, my wife is using bio identical compounded cream prescribed from our doctor, and sourced from Women's International Pharmacy, it contains progesterone, two types of estrogen, and testosterone, she rubs a bit on her arms and legs twice a day. The doctor has quite a bit of room to play with the testosterone levels until libido is restored. Your wife will feel much better, more energy, clearer thinking (CRS gets much better, the "can't remember shit" syndrome caused by menopause), no hot flashes, sleep better, feel more calm, less risk of cancer. All hormones need to be balanced by blood testing, even thyroid and vitamin D (a hormone). We both do blood work every six months. We also take other supplements that have helped with feeling well....fish oil, B complex with methyl folate, CoQ10, K2, Longvida, oil based D3, selenium, magnesium, and D-mannose. http://www.lifeextension.com/magazine/2004/4/report_test/page-01