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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Trimix: How Long Can it Stay Off Refrigeration?
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<blockquote data-quote="Nelson Vergel" data-source="post: 83399" data-attributes="member: 3"><p>Int J Pharm Compd. 2004 May-Jun;8(3):231-5.</p><p><strong>Long-term stability of trimix: a three-drug injection used to treat erectile dysfunction.</strong></p><p></p><p>Trissel LA1, Zhang Y.</p><p></p><p>Abstract</p><p></p><p>A three-drug injection mixture of alprostadil 12.5 microgram/mL, papaverine hydrochloride 4.5 mg/mL and phentolamine mesylate 0.125 mg/mL in bacteriostatic 0.9% sodium chloride injection was evaluated for <strong>stability at 23 deg C, 4 deg C, -20 deg C and -70 deg C.</strong> The injection remained clear and colorless in all samples throughout the study. Chemical stability testing was performed using stability-indicating high-performance liquid chromatographic analysis. Alprostadil was the least stable of the drug components at room temperature and under refrigeration. <strong>About 8% alprostadil loss occurred in five days at room temperature; under refrigeration losses of about 6% and 11% occurred after 1 and 2 months, respectively. </strong>Frozen at -20 deg C and -70 deg C, less than 5% loss of any of the drug componnets occurred in 6 months. A beyond-use date of 6 months when stored frozen at -20 deg C and 1 month when stored refrigerated at 4 deg C is appropriate for batches of the injection that have passed sterility testing. Room temperature exposure should be limited, and the vial should be returned to refrigeration as soon as possible.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 83399, member: 3"] Int J Pharm Compd. 2004 May-Jun;8(3):231-5. [B]Long-term stability of trimix: a three-drug injection used to treat erectile dysfunction.[/B] Trissel LA1, Zhang Y. Abstract A three-drug injection mixture of alprostadil 12.5 microgram/mL, papaverine hydrochloride 4.5 mg/mL and phentolamine mesylate 0.125 mg/mL in bacteriostatic 0.9% sodium chloride injection was evaluated for [B]stability at 23 deg C, 4 deg C, -20 deg C and -70 deg C.[/B] The injection remained clear and colorless in all samples throughout the study. Chemical stability testing was performed using stability-indicating high-performance liquid chromatographic analysis. Alprostadil was the least stable of the drug components at room temperature and under refrigeration. [B]About 8% alprostadil loss occurred in five days at room temperature; under refrigeration losses of about 6% and 11% occurred after 1 and 2 months, respectively. [/B]Frozen at -20 deg C and -70 deg C, less than 5% loss of any of the drug componnets occurred in 6 months. A beyond-use date of 6 months when stored frozen at -20 deg C and 1 month when stored refrigerated at 4 deg C is appropriate for batches of the injection that have passed sterility testing. Room temperature exposure should be limited, and the vial should be returned to refrigeration as soon as possible. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Trimix: How Long Can it Stay Off Refrigeration?
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