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Mental Health
Treatments for Anhedonia/Blunting
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<blockquote data-quote="electrify" data-source="post: 259336" data-attributes="member: 44439"><p>That is really interesting. I wonder what mechanism leads to that. I always had a feeling keeping things too stable isn't great. </p><p></p><p>I see that low dose Selegiline an MAOI is also mentioned in that thread which is something I was considering to get me out of this episode as well. But right now 30 mg MB + 1.5 mg LDN are having benefits so im sticking to those. But Selegiline only inhibits MAO-B at low doses whereas I think MB inhibits MAO-A which I also think the latter is more needed.</p><p></p><p></p><p></p><p></p><p>They might be yea. I've seen some other reports of people having bad reactions to stuff post-covid. I dug out some 23andme gene results recently from years ago and it turns out both my MAO-A and MAO-B activity is high, and COMT high too so there is a good chance my dopamine is easily lowered or hard to recover. </p><p></p><p>I mentioned GABA because even though anxiety isn't an issue, stuff like Chamomile tea (has Apigenin which is GABAergic) very slightly helps too. And my initial response to Allopreg or Etifoxine. They are actually coming up with Zuranolone an allopreg analog soon for MDD, so I suspect the GABA system is involved in more than just anxiety/sleep. I hope it gets approved, we find out in about 2 weeks</p></blockquote><p></p>
[QUOTE="electrify, post: 259336, member: 44439"] That is really interesting. I wonder what mechanism leads to that. I always had a feeling keeping things too stable isn't great. I see that low dose Selegiline an MAOI is also mentioned in that thread which is something I was considering to get me out of this episode as well. But right now 30 mg MB + 1.5 mg LDN are having benefits so im sticking to those. But Selegiline only inhibits MAO-B at low doses whereas I think MB inhibits MAO-A which I also think the latter is more needed. They might be yea. I've seen some other reports of people having bad reactions to stuff post-covid. I dug out some 23andme gene results recently from years ago and it turns out both my MAO-A and MAO-B activity is high, and COMT high too so there is a good chance my dopamine is easily lowered or hard to recover. I mentioned GABA because even though anxiety isn't an issue, stuff like Chamomile tea (has Apigenin which is GABAergic) very slightly helps too. And my initial response to Allopreg or Etifoxine. They are actually coming up with Zuranolone an allopreg analog soon for MDD, so I suspect the GABA system is involved in more than just anxiety/sleep. I hope it gets approved, we find out in about 2 weeks [/QUOTE]
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Treatments for Anhedonia/Blunting
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