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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Treating Low Testosterone with Clomid, hCG and Aromatase Inhibitors: A Review of the Data
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<blockquote data-quote="madman" data-source="post: 176377" data-attributes="member: 13851"><p>Some important points:</p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">*</span><span style="color: rgb(26, 188, 156)"><u>AAS can also bind the androgen receptor inside target cells</u> </span>and bring into play the same negative feedback effects as endogenous testosterone.</strong></p><p><strong></strong></p><p><strong><span style="color: rgb(184, 49, 47)">*<u>Androgens, as well as estrogens and progestins,</u></span> in turn, cause negative feedback inhibition at the hypothalamus and pituitary, lowering the output of gonadotropins and testosterone when too much hormone is present.</strong></p><p><strong></strong></p><p><strong><span style="color: rgb(184, 49, 47)">*<u>Additional autocrine, paracrine, and endocrine factors within the hypothalamus, pituitary, and testis can function to further modulate the HPG axis in complex ways including endocannabinoids, GnRH, kisspeptin, norepinephrine, growth hormone, interleukins, and TGF-β </u>28.</span> Therefore, the HPG axis represents a dynamic, but tightly regulated, system at multiple levels resulting in spermatogenesis, among other things.</strong></p><p><strong></strong></p><p><strong><span style="color: rgb(184, 49, 47)">*</span>Regulation of the secretion of GnRH, FSH, and LH occurs partially by the negative feedback of testosterone and estradiol at the level of the hypothalamo-pituitary. <span style="color: rgb(184, 49, 47)"><u>Estradiol has a much larger, inhibitory effect than testosterone, being 200-fold more effective in suppressing LH secretion </u>[57–61].</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 176377, member: 13851"] Some important points: [B][COLOR=rgb(184, 49, 47)]*[/COLOR][COLOR=rgb(26, 188, 156)][U]AAS can also bind the androgen receptor inside target cells[/U] [/COLOR]and bring into play the same negative feedback effects as endogenous testosterone. [COLOR=rgb(184, 49, 47)]*[U]Androgens, as well as estrogens and progestins,[/U][/COLOR] in turn, cause negative feedback inhibition at the hypothalamus and pituitary, lowering the output of gonadotropins and testosterone when too much hormone is present. [COLOR=rgb(184, 49, 47)]*[U]Additional autocrine, paracrine, and endocrine factors within the hypothalamus, pituitary, and testis can function to further modulate the HPG axis in complex ways including endocannabinoids, GnRH, kisspeptin, norepinephrine, growth hormone, interleukins, and TGF-β [/U]28.[/COLOR] Therefore, the HPG axis represents a dynamic, but tightly regulated, system at multiple levels resulting in spermatogenesis, among other things. [COLOR=rgb(184, 49, 47)]*[/COLOR]Regulation of the secretion of GnRH, FSH, and LH occurs partially by the negative feedback of testosterone and estradiol at the level of the hypothalamo-pituitary. [COLOR=rgb(184, 49, 47)][U]Estradiol has a much larger, inhibitory effect than testosterone, being 200-fold more effective in suppressing LH secretion [/U][57–61].[/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Treating Low Testosterone with Clomid, hCG and Aromatase Inhibitors: A Review of the Data
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