ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Treating Low Testosterone with Clomid, hCG and Aromatase Inhibitors: A Review of the Data
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 175752" data-attributes="member: 13851"><p><strong>Abstract</strong></p><p></p><p><em>Testosterone deficiency is defined as a total testosterone level <300 ng/dL confirmed on two early morning lab draws. Testosterone therapy has historically been offered to men with symptomatic testosterone deficiency in the form of injections, gels, or pellets. However, these treatments are invasive or have undesirable effects including the risk of drug transference. Additionally, testosterone therapy has been associated with increases in hematocrit and controversy remains regarding the risk of cardiovascular and thromboembolic events while on testosterone therapy. As such, much interest has recently been focused on alternative treatment options for testosterone deficiency in the form of orally-administered medications with more favorable side effect profiles. Lifestyle modifications and varicocelectomy have been shown to raise endogenous testosterone production. Similarly, SERMs and aromatase inhibitors (AIs) have been shown to raise testosterone levels safely and effectively. Human chorionic gonadotropin (hCG) remains the only FDA-approved non-testosterone treatment option for testosterone deficiency in men. However, this medication is expensive and requires patient-administered injections. Over-the-counter herbal supplements and designer steroids remain available though they are poorly studied and are associated with the potential for abuse as well as increased hepatic and cardiovascular risks. This review aims to discuss the existing treatment alternatives to traditional testosterone therapy, including the efficacy, safety, and side effects of these options. The authors suggest that the SERM clomiphene citrate (CC) holds the greatest promise as a nontestosterone treatment option for testosterone deficiency.</em></p><p><em></em></p><p><em></em></p><p></p><p></p><p><strong>Conclusions </strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><em><strong>Given the prevalence of testosterone deficiency in men, and the desire to avoid testosterone therapy and its associated effects on testicular volume, spermatogenesis, and the HPG axis with possible adverse side effects, much work has been done to identify safe and efficacious alternative treatment options.</strong></em></span><strong><em> <span style="color: rgb(44, 130, 201)">Lifestyle modifications are safe and have been shown to increase endogenous testosterone production and should be offered to all men desiring treatment for testosterone deficiency. Varicocelectomy, with further study, may become a valid treatment option in the presence of a clinical varicocele. While numerous compounds exist marketed towards “boosting testosterone,” data on the safety and efficacy of these are poor, and these are not currently recommended as treatments for testosterone deficiency.</span><span style="color: rgb(26, 188, 156)"> Gonadotropins, including hCG (the only non-testosterone agent FDA-approved for the treatment of male hypogonadism), are effective, but costly and require administration via injection. </span><span style="color: rgb(184, 49, 47)"><strong>AIs may also raise testosterone levels but may be associated with decreases in bone mineral density if used long-term.</strong></span><span style="color: rgb(26, 188, 156)"> SERMs, including clomiphene citrate, appear to be highly effective at producing physiologic testosterone levels and appear to be well tolerated and safe when used long-term. Consideration may be given to offering clomiphene citrate to men with symptomatic testosterone, regardless of the patient’s desire to preserve fertility. </span>While studies exist suggesting that many of these treatment options are well tolerated and efficacious, further prospective studies must be conducted to support their use as first-line treatment options in the management of testosterone deficiency.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 175752, member: 13851"] [B]Abstract[/B] [I]Testosterone deficiency is defined as a total testosterone level <300 ng/dL confirmed on two early morning lab draws. Testosterone therapy has historically been offered to men with symptomatic testosterone deficiency in the form of injections, gels, or pellets. However, these treatments are invasive or have undesirable effects including the risk of drug transference. Additionally, testosterone therapy has been associated with increases in hematocrit and controversy remains regarding the risk of cardiovascular and thromboembolic events while on testosterone therapy. As such, much interest has recently been focused on alternative treatment options for testosterone deficiency in the form of orally-administered medications with more favorable side effect profiles. Lifestyle modifications and varicocelectomy have been shown to raise endogenous testosterone production. Similarly, SERMs and aromatase inhibitors (AIs) have been shown to raise testosterone levels safely and effectively. Human chorionic gonadotropin (hCG) remains the only FDA-approved non-testosterone treatment option for testosterone deficiency in men. However, this medication is expensive and requires patient-administered injections. Over-the-counter herbal supplements and designer steroids remain available though they are poorly studied and are associated with the potential for abuse as well as increased hepatic and cardiovascular risks. This review aims to discuss the existing treatment alternatives to traditional testosterone therapy, including the efficacy, safety, and side effects of these options. The authors suggest that the SERM clomiphene citrate (CC) holds the greatest promise as a nontestosterone treatment option for testosterone deficiency. [/I] [B]Conclusions [/B] [COLOR=rgb(184, 49, 47)][I][B]Given the prevalence of testosterone deficiency in men, and the desire to avoid testosterone therapy and its associated effects on testicular volume, spermatogenesis, and the HPG axis with possible adverse side effects, much work has been done to identify safe and efficacious alternative treatment options.[/B][/I][/COLOR][B][I] [COLOR=rgb(44, 130, 201)]Lifestyle modifications are safe and have been shown to increase endogenous testosterone production and should be offered to all men desiring treatment for testosterone deficiency. Varicocelectomy, with further study, may become a valid treatment option in the presence of a clinical varicocele. While numerous compounds exist marketed towards “boosting testosterone,” data on the safety and efficacy of these are poor, and these are not currently recommended as treatments for testosterone deficiency.[/COLOR][COLOR=rgb(26, 188, 156)] Gonadotropins, including hCG (the only non-testosterone agent FDA-approved for the treatment of male hypogonadism), are effective, but costly and require administration via injection. [/COLOR][COLOR=rgb(184, 49, 47)][B]AIs may also raise testosterone levels but may be associated with decreases in bone mineral density if used long-term.[/B][/COLOR][COLOR=rgb(26, 188, 156)] SERMs, including clomiphene citrate, appear to be highly effective at producing physiologic testosterone levels and appear to be well tolerated and safe when used long-term. Consideration may be given to offering clomiphene citrate to men with symptomatic testosterone, regardless of the patient’s desire to preserve fertility. [/COLOR]While studies exist suggesting that many of these treatment options are well tolerated and efficacious, further prospective studies must be conducted to support their use as first-line treatment options in the management of testosterone deficiency.[/I][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Treating Low Testosterone with Clomid, hCG and Aromatase Inhibitors: A Review of the Data
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top