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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Transdermal progesterone use in men
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<blockquote data-quote="sammmy" data-source="post: 192280" data-attributes="member: 38594"><p>Oily solutions (SFA esters) are not feasible for everyday application on scalp, unless you are bald and woul like to "shine like a star".</p><p></p><p>Progesterone solubility in ethanol is about 1%, which should be sufficient for topical hair growth and for helping with sleep (1 gram of solution will be 10mg progesterone, of which about 1mg will be absorbed transdermally).</p><p></p><p>I've read in a review that progesterone solubility and bioavailability is hugely increased by complexing with methylated cyclodextrin which is highly hydrophilic.</p><p></p><p>Methyl-beta-cyclodextrin can be found online but is severely overpriced. The similar 2-Hydroxypropyl-beta-cyclodextrin can be found on ebay and Amazon about 10 times cheaper. I still don't know what is meant by 'complexing' but a wild guess is that just mixing a water solution of the cyclodextrin with progesterone and stirring with a mixer should make the molecules form complexes with each other.</p></blockquote><p></p>
[QUOTE="sammmy, post: 192280, member: 38594"] Oily solutions (SFA esters) are not feasible for everyday application on scalp, unless you are bald and woul like to "shine like a star". Progesterone solubility in ethanol is about 1%, which should be sufficient for topical hair growth and for helping with sleep (1 gram of solution will be 10mg progesterone, of which about 1mg will be absorbed transdermally). I've read in a review that progesterone solubility and bioavailability is hugely increased by complexing with methylated cyclodextrin which is highly hydrophilic. Methyl-beta-cyclodextrin can be found online but is severely overpriced. The similar 2-Hydroxypropyl-beta-cyclodextrin can be found on ebay and Amazon about 10 times cheaper. I still don't know what is meant by 'complexing' but a wild guess is that just mixing a water solution of the cyclodextrin with progesterone and stirring with a mixer should make the molecules form complexes with each other. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Transdermal progesterone use in men
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